Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Table 8 Characteristics and outcome of feline patients treated with pump inhibitors and chemotherapy

PATIENT	AGE	TUMOR	PREV. TREATMENT	THERAPY	OUTCOME (MONTHS)
DSH	10	BREAST CARCINOMA	SURGERY MITOXANTRONE PD	MITOXANTRONE	PR 4
DSH	12	ORAL SCC	MITOXANTRONE PD	MITOXANTRONE	SD 2
DSH	10	ORAL SCC	SURGERY MITOXANTRONE PD	MITOXANTRONE	CR 5+
DSH	12	ORAL SCC	BIOPSY MITOXANTRONE PD	MITOXANTRONE	SD 6
DSH	12	LSA	MOPP × 3 months	MOPP	CR 6+
DSH	8	NASAL LSA	MOPP PD	MOPP	PR 3+
DSH	7	FSA	SURGERY, ECT × 2, CARBOPLATIN × 2 MITOXANTRONE × 2	MITOXANTRONE	PD

Abbreviations: DSH: domestic short hair; ECT: electrochemotherapy; FSA: fibrosarcoma; LSA: lymphosarcoma; MOPP: mechlorethamine, oncovin (vincristine), prednisone, procarbazine; SCC: squamous cell carcinoma. +: still alive.
Drugs schedule: doxorubicin 30 mg/m² every 21 days (pending hematological, cardiac and renal evaluation) up to 6 doses, carboplatin 210 mg/m² every 21 days, mitoxantrone 6 mg/m² every 21 days. For MOPP protocol see table 4 and 5.

ISSN: 1479-5876