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Table 8 Characteristics and outcome of feline patients treated with pump inhibitors and chemotherapy

From: Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

PATIENT AGE TUMOR PREV.
TREATMENT
THERAPY OUTCOME
(MONTHS)
DSH 10 BREAST
CARCINOMA
SURGERY
MITOXANTRONE
PD
MITOXANTRONE PR 4
DSH 12 ORAL SCC MITOXANTRONE
PD
MITOXANTRONE SD 2
DSH 10 ORAL SCC SURGERY
MITOXANTRONE
PD
MITOXANTRONE CR 5+
DSH 12 ORAL SCC BIOPSY
MITOXANTRONE
PD
MITOXANTRONE SD 6
DSH 12 LSA MOPP
× 3 months
MOPP CR 6+
DSH 8 NASAL LSA MOPP
PD
MOPP PR 3+
DSH 7 FSA SURGERY,
ECT × 2,
CARBOPLATIN
× 2
MITOXANTRONE
× 2
MITOXANTRONE PD
  1. Abbreviations: DSH: domestic short hair; ECT: electrochemotherapy; FSA: fibrosarcoma; LSA: lymphosarcoma; MOPP: mechlorethamine, oncovin (vincristine), prednisone, procarbazine; SCC: squamous cell carcinoma. +: still alive.
  2. Drugs schedule: doxorubicin 30 mg/m2 every 21 days (pending hematological, cardiac and renal evaluation) up to 6 doses, carboplatin 210 mg/m2 every 21 days, mitoxantrone 6 mg/m2 every 21 days. For MOPP protocol see table 4 and 5.