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Table 4 Madison Wisconsin lymphoma protocol

From: Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Week 1:

 

Vincristine 0.7 mg/m2 IV

  

Asparaginase 400 IU/kg IM

  

Pre-med with chlorphenamine: small-medium 2.5-

  

5 mg IM; medium-large 5-10 mg IM

  

Prednisolone 2 mg/kg PO SID

 

Start antacids:

zantac 2 mg/kg PO BID

  

antepsin < 20 kg 500 mg, > 20 kg 1-2 g PO TID

Week 2:

 

Cyclophosphamide 250 mg/m2 PO or IV (+ NaCl)

  

Prednisolone 1.5 mg/kg PO SID

 

Stop antacids:

after week 2

Week 3:

 

Vincristine 0.7 mg/m2 IV

  

Prednisolone 1 mg/kg PO SID

Week 4:

 

Doxorubicin 30 mg/m2 IV (+ 0.9% NaCl)

  

Pre-med with chlorphenamine and

  

metoclopramide 0.5-1 mg/kg IM/SC)

  

Prednisolone 0.5 mg/kg PO SID

Week 6:

 

Vincristine 0.7 mg/m2 IV

Week 7:

 

Cyclophosphamide 250 mg/m2 PO or IV (+ NaCl)

Week 8:

 

Vincristine 0.7 mg/m2 IV

Week 9:

 

Doxorubicin 30 mg/m2 IV (+ 0.9% NaCl)

Pre-med with chlorphenamine + metoclopramide

Week 11:

 

Vincristine 0.7 mg/m2 IV

Week 13:

 

Cyclophosphamide 250 mg/m2 PO or IV (+ NaCl)

Week 15:

 

Vincristine 0.7 mg/m2 IV

Week 17:

 

Doxorubicin 30 mg/m2 IV (+ 0.9% NaCl)

Pre-med with chlorphenamine + metoclopramide

Week 19:

 

Vincristine 0.7 mg/m2 IV

Week 21:

 

Cyclophosphamide 250 mg/m2 PO or IV (+ NaCl)

Week 23:

 

Vincristine 0.7 mg/m2 IV

Week 25:

 

Doxorubicin 30 mg/m2 IV (+ 0.9% NaCl)

Pre-med with chlorphenamine + metoclopramide

  1. BLOODS:
  2. Haematology: prior to each dose
  3. Urine:- Dipstick after every cyclophosphamide dose
  4. - Full urinalysis after week 7
  5. CARDIAC SCAN:
  6. At time of: - First doxorubicin dose
  7. - Last doxorubicin dose
  8. - 3 months post protocol completion
  9. REPEAT VISITS:
  10. If in complete remission, checks should be made at months 1, 2, 3 and 6
  11. NOTES:
  12. • For dogs < 10 Kg, use a 1 mg/Kg dose of doxorubicin.
  13. • All treatment is discontinued after week 25 if in complete remission.
  14. • If neutrophil count is < 3 × 109/L wait 5-7 days and repeat haematology before giving chemo.
  15. • If sterile haemorrhagic cystitis occurs on cyclophosphamide, discontinue and substitute Chlorambuci l (1.4 mg/kg PO) for subsequently scheduled cyclophosphamide injections.
  16. • You can administer L-asparaginase (400 IU/kg IM) with each vincristine injection until CR is achieved.
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Journal of Translational Medicine

ISSN: 1479-5876

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