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Figure 1 | Journal of Translational Medicine

Figure 1

From: TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

Figure 1

Neutrophil infiltration into pancreatic tissue nine hours after administration of heparan sulphate (A), lipopolysaccharide (B) and PBS (C), illustrated by NIMP-R14 positive cells. Neutrophil sequestration (D) and MPO activity (E) during 48 hours after infusion is illustrated. Neutrophil recruitment significantly increased at 3, 6 and 9 hours in the LPS treated and at 9 hours in the HS treated group compared to the PBS group. *P < 0.05 **P < 0.01 ***P < 0.001 PBS, phosphate-buffered saline, HS, heparan sulphate, LPS, lipopolysaccharide and healthy refers to untreated animals.

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