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Table 3 GMSP assay-generated profile of skewed TCRBV gene families in CD8+ and CD8- cells in patients with CSHB.

From: Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B

Patients no.

CD8+ cells

CD8- cells

 

Skewed TCRBV

Monoclone

Skewed TCRBV

Monoclone

1

3, 5.2, 7, 13.1, 18, 20

7, 13.1

7, 11

7, 11

2

5.1, 5.2, 7, 11, 12, 21, 22, 24

11

None

None

3

3, 5.1, 17, 20, 23

None

2, 7, 11, 20

11, 20

4

4, 5.2, 11, 12, 18, 21, 22

11

7, 11

None

5

2, 13.2, 15, 16

2, 16

4, 13.1

None

6

3, 5.2, 17, 22

17

5.1, 11, 17, 22, 23

11

7

4, 6, 8, 11, 12

11

4, 7, 11

4, 7, 11

8

None

None

None

None

9

6, 8, 11, 13.1, 13.2, 14, 16, 22

11, 13.1

5.1, 11, 17, 22, 23

11

10

9, 11, 13.1, 13.2, 16, 17, 21, 22, 24

11, 13.2

5.1, 12, 20

None

11

2, 5.2, 9, 11, 12, 14, 15,18

5.2, 11, 18

11, 20, 24

11, 24

12

3, 7, 11, 13.1, 20, 21

7, 11, 20

4

4

13

2, 5.1, 6, 13.2, 17, 18, 22, 24

6, 17

10, 11, 15, 22

11

14

1, 4, 7, 11, 17, 18

11, 18

5.2, 7, 11, 18, 20

11, 18

15

2, 5.2, 12, 13.2, 20

None

12, 21

None

Total no. of altered (skewed) TCRBV families (no. of patients)

89 (15)a

22 (15)b

41 (15)a

15 (15)b

  1. a The rate of skewed TCRBV families was higher in CD8+ cells than in CD8- cells (P < 0.01 by χ2 test). b The monoclonal rate was not significantly different between the two groups (P > 0.05 by χ2 test).