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Table 3 GMSP assay-generated profile of skewed TCRBV gene families in CD8+ and CD8- cells in patients with CSHB.

From: Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B

Patients no. CD8+ cells CD8- cells
  Skewed TCRBV Monoclone Skewed TCRBV Monoclone
1 3, 5.2, 7, 13.1, 18, 20 7, 13.1 7, 11 7, 11
2 5.1, 5.2, 7, 11, 12, 21, 22, 24 11 None None
3 3, 5.1, 17, 20, 23 None 2, 7, 11, 20 11, 20
4 4, 5.2, 11, 12, 18, 21, 22 11 7, 11 None
5 2, 13.2, 15, 16 2, 16 4, 13.1 None
6 3, 5.2, 17, 22 17 5.1, 11, 17, 22, 23 11
7 4, 6, 8, 11, 12 11 4, 7, 11 4, 7, 11
8 None None None None
9 6, 8, 11, 13.1, 13.2, 14, 16, 22 11, 13.1 5.1, 11, 17, 22, 23 11
10 9, 11, 13.1, 13.2, 16, 17, 21, 22, 24 11, 13.2 5.1, 12, 20 None
11 2, 5.2, 9, 11, 12, 14, 15,18 5.2, 11, 18 11, 20, 24 11, 24
12 3, 7, 11, 13.1, 20, 21 7, 11, 20 4 4
13 2, 5.1, 6, 13.2, 17, 18, 22, 24 6, 17 10, 11, 15, 22 11
14 1, 4, 7, 11, 17, 18 11, 18 5.2, 7, 11, 18, 20 11, 18
15 2, 5.2, 12, 13.2, 20 None 12, 21 None
Total no. of altered (skewed) TCRBV families (no. of patients) 89 (15)a 22 (15)b 41 (15)a 15 (15)b
  1. a The rate of skewed TCRBV families was higher in CD8+ cells than in CD8- cells (P < 0.01 by χ2 test). b The monoclonal rate was not significantly different between the two groups (P > 0.05 by χ2 test).