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Table 2 The frequency of skewed TCRBV in CD8+ and CD8- cells (PBMCs excluding CD8+ cell) and PBMCs from patients with CSHBa.

From: Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B

TCRBV families CD8+ cell Incidence (%)b CD8- PBMC Incidence (%)b Total PBMCs Incidence (%)b
1 2 0 3
2 4 (28.6) 1 4
3 3 0 4
4 3 3 6
5.1 4 (28.6) 3 7 (28)
5.2 5 (35.7) 1 4
6 3 0 4
7 4 (28.6) 5 (38.5) 9 (36)
8 2 0 7 (28)
9 2 0 6
10 0 1 2
11 9 (64.3) 9 (69.2) 15 (60)
12 5 (35.7) 2 6
13.1 3 1 7 (28)
13.2 5 (35.7) 0 7 (28)
14 2 0 3
15 2 1 2
16 3 0 3
17 5 (35.7) 2 5
18 5 (35.7) 1 8 (32)
19 0 0 1
20 4 (28.6) 4 (30.1) 4
21 4 (28.6) 1 3
22 6 (42.9) 3 5
23 1 2 5
24 3 1 1
Total no. of skewed Vβ
(average ratio for a case)
89 (6.36)c, d 41 (3.15)c 131 (5.24)c, d
No. of patients examined
with normal pattern (ratio, %)
1 (6.67)e 2 (13.33)e 2 (7.41)e
No. of patients examined 15 15 27
  1. aThe number of TCRBV gene families showing skewed-clone expansion (oligoclonal or monoclonal) is summarized in patients with CSHB.
  2. bThe number of samples showing a skewed-clone expansion in total detected samples (percentages of each TCRBV skewed-clone expansion). Samples with normal GMSP (no skewed-clone expansion pattern) are excluded in the percentage calculation.
  3. cThe average expansion rate of TCRBV gene families was lower in CD8- PBMC (depleted CD8+ cells) than in other two cell populations (P < 0.01 by χ2 test). dThere was no significant difference between the two groups (P > 0.05 by χ2 test). Sample with normal GMSP (no skewed-clone expansion pattern) are excluded in the average ratio calculation.
  4. eThe incidence of the normal GMSP was significantly higher in CD8- PBMC (depleted CD8+ cells) than in other two cell populations (P < 0.01 by χ2 test).