Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B

Table 2 The frequency of skewed TCRBV in CD8⁺ and CD8^- cells (PBMCs excluding CD8⁺ cell) and PBMCs from patients with CSHB^a.

TCRBV families	CD8⁺ cell Incidence (%)^b	CD8^- PBMC Incidence (%)^b	Total PBMCs Incidence (%)^b
1	2	0	3
2	4 (28.6)	1	4
3	3	0	4
4	3	3	6
5.1	4 (28.6)	3	7 (28)
5.2	5 (35.7)	1	4
6	3	0	4
7	4 (28.6)	5 (38.5)	9 (36)
8	2	0	7 (28)
9	2	0	6
10	0	1	2
11	9 (64.3)	9 (69.2)	15 (60)
12	5 (35.7)	2	6
13.1	3	1	7 (28)
13.2	5 (35.7)	0	7 (28)
14	2	0	3
15	2	1	2
16	3	0	3
17	5 (35.7)	2	5
18	5 (35.7)	1	8 (32)
19	0	0	1
20	4 (28.6)	4 (30.1)	4
21	4 (28.6)	1	3
22	6 (42.9)	3	5
23	1	2	5
24	3	1	1
Total no. of skewed Vβ (average ratio for a case)	89 (6.36)^{c, d}	41 (3.15)^c	131 (5.24)^{c, d}
No. of patients examined with normal pattern (ratio, %)	1 (6.67)^e	2 (13.33)^e	2 (7.41)^e
No. of patients examined	15	15	27

^aThe number of TCRBV gene families showing skewed-clone expansion (oligoclonal or monoclonal) is summarized in patients with CSHB.
^bThe number of samples showing a skewed-clone expansion in total detected samples (percentages of each TCRBV skewed-clone expansion). Samples with normal GMSP (no skewed-clone expansion pattern) are excluded in the percentage calculation.
^cThe average expansion rate of TCRBV gene families was lower in CD8^- PBMC (depleted CD8⁺ cells) than in other two cell populations (P < 0.01 by χ² test). ^dThere was no significant difference between the two groups (P > 0.05 by χ² test). Sample with normal GMSP (no skewed-clone expansion pattern) are excluded in the average ratio calculation.
^eThe incidence of the normal GMSP was significantly higher in CD8^- PBMC (depleted CD8⁺ cells) than in other two cell populations (P < 0.01 by χ² test).

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