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Figure 5 | Journal of Translational Medicine

Figure 5

From: Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model

Figure 5

Effect of hAAT gene therapy on auto-antibody production. Anti-CII antibodies at day 28, 42 and 56 were tested by ELISA. Black bars represent the average levels (n = 10, mean+SD) (relative units) of antibodies in hAAT gene therapy treated group. Open bars represent the average levels (n = 10, relative units, mean+SD) of antibodies in saline injected group. (A) Antibody levels against bovine CII (bCII). Top left panel, total Ig antibodies against bCII (total anti-bCII-Ig); Top right panel, levels of IgG2a anti-bCII (anti-bCII-IgG2a); Bottom left panel, levels of IgG1 anti-bCII (anti-bCII-IgG1); Bottom right panel, the ratio of anti-bCII-IgG2a to anti-bCII-IgG1 (anti-bCII-IgG2a/IgG1 ratio). (B) Antibody levels against mouse CII (mCII). Top left panel, total Ig antibodies against mCII (total anti-mCII-Ig); Top right panel, levels of IgG2a anti-mCII (anti-mCII-IgG2a); Bottom left panel, levels of IgG1 anti-mCII (anti-mCII-IgG1); Bottom right panel, the ratio of anti-mCII-IgG2a to anti-mCII-IgG1 (anti-mCII-IgG2a/IgG1). *p < 0.05, **p < 0.01, ***p < 0.001 by Mann-Whitney U- test.

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