Table 1 Beneficial and non-beneficial OLP identified in Lima clade B cohort (p < 0.05)
From: Definition of the viral targets of protective HIV-1-specific T cell responses
OLP # | Protein | Sub-unit | OLP clade B consensus sequence | Median viral load in OLP responders | Median viral load in OLP non-responders | Protective Ratio (PR)* | p-value |
|---|---|---|---|---|---|---|---|
3 | Gag | p17 | EKIRLRPGGKKKYKLKHI | 22947 | 39014 | 1.053 | 0.037 |
6 | Gag | p17 | ASRELERFAVNPGLL | 15380 | 43189 | 1.107 | 0.001 |
7 | Gag | p17 | ERFAVNPGLLETSEGCR | 25939 | 38974 | 1.040 | 0.049 |
10 | Gag | p17 | QLQPSLQTGSEELRSLY | 16285 | 37237 | 1.085 | 0.031 |
12 | Gag | p17 | SLYNTVATLYCVHQRIEV | 23855 | 37113 | 1.044 | 0.037 |
23 | Gag | p24 | AFSPEVIPMFSALSEGA | 22947 | 37113 | 1.048 | 0.036 |
31 | Gag | p24 | IAPGQMREPRGSDIA | 3563 | 35483 | 1.281 | 0.028 |
34 | Gag | p24 | STLQEQIGWMTNNPPIPV | 6127 | 37360 | 1.207 | 0.002 |
48 | Gag | p24 | ACQGVGGPGHKARVLAEA | 12975 | 35755 | 1.107 | 0.041 |
60 | Gag | p15 | GKIWPSHKGRPGNFLQSR | 16266 | 36434 | 1.083 | 0.044 |
75 | Nef | - | WLEAQEEEEVGFPVRPQV | 13407 | 37360 | 1.108 | 0.026 |
76 | Nef | - | EVGFPVRPQVPLRPMTYK | 59618 | 29855 | 0.937 | 0.001 |
84 | Nef | - | NYTPGPGIRYPLTFGWCF | 55402 | 30538 | 0.945 | 0.006 |
85 | Nef | - | RYPLTFGWCFKLVPV | 69890 | 29903 | 0.924 | 0.002 |
90 | Nef | - | SLHGMDDPEKEVLVWKF | 89687 | 32650 | 0.911 | 0.042 |
159 | Pol | Pro | KMIGGIGGFIKVRQYDQI | 14736 | 36434 | 1.094 | 0.020 |
160 | Pol | Pro | FIKVRQYDQILIEICGHK | 3682 | 35755 | 1.277 | 0.031 |
161 | Pol | Pro | QILIEICGHKAIGTVLV | 9117 | 35483 | 1.149 | 0.050 |
163 | Pol | Pro | LVGPTPVNIIGRNLLTQI | 25965 | 45637 | 1.055 | 0.007 |
171 | Pol | RT | LVEICTEMEKEGKISKI | 1865 | 35483 | 1.391 | 0.014 |
181 | Pol | RT | LDVGDAYFSVPLDKDFRK | 65858 | 32871 | 0.937 | 0.041 |
195 | Pol | RT | LRWGFTTPDKKHQKEPPF | 5624 | 37113 | 1.219 | 0.006 |
196 | Pol | RT | DKKHQKEPPFLWMGYELH | 10103 | 35483 | 1.136 | 0.044 |
210 | Pol | RT | EIQKQGQGQWTYQIY | 18155 | 35483 | 1.068 | 0.045 |
222 | Pol | RT | PPLVKLWYQLEKEPIVGA | 412599 | 34640 | 0.808 | 0.030 |
230 | Pol | RT | IHLALQDSGLEVNIV | 85102 | 34117 | 0.919 | 0.030 |
237 | Pol | RT | VYLAWVPAHKGIGGNEQV | 85102 | 34117 | 0.919 | 0.029 |
240 | Pol | RT | SAGIRKVLFLDGIDKA | 116902 | 32761 | 0.891 | 0.019 |
269 | Pol | Int | TKELQKQITKIQNFRVYY | 6629 | 35755 | 1.192 | 0.030 |
270 | Pol | Int | TKIQNFRVYYRDSRDPLW | 18171 | 37360 | 1.073 | 0.019 |
271 | Pol | Int | YYRDSRDPLWKGPAKLLW | 25939 | 35755 | 1.032 | 0.043 |
276 | Pol | Int | KIIRDYGKQMAGDDCVA | 6629 | 35755 | 1.192 | 0.021 |
279 | Vpr | - | GPQREPYNEWTLELLEEL | 60222 | 32650 | 0.944 | 0.042 |
307 | Env | Gp120 | DLNNNTNTTSSSGEKMEK | 179419 | 34117 | 0.863 | 0.044 |
311 | Env | Gp120 | IRDKVQKEYALFYKLDVV | 179419 | 32871 | 0.860 | 0.008 |
314 | Env | Gp120 | YRLISCNTSVITQACPKV | 58206 | 31273 | 0.943 | 0.008 |
315 | Env | Gp120 | SVITQACPKVSFEPIPIH | 61011 | 32871 | 0.944 | 0.034 |
320 | Env | Gp120 | TNVSTVQCTHGIRPVV | 341587 | 34640 | 0.820 | 0.034 |
355 | Env | Gp120 | VAPTKAKRRVVQREKRAV | 161602 | 34117 | 0.870 | 0.042 |
399 | Env | Gp41 | VIEVVQRACRAILHIPRR | 388089 | 34640 | 0.812 | 0.026 |
405 | Vif | - | VKHHMYISGKAKGWFYRH | 16458 | 37237 | 1.084 | 0.021 |
406 | Vif | - | GKAKGWFYRHHYESTHPR | 16458 | 37237 | 1.084 | 0.022 |
424 | Vif | - | TKLTEDRWNKPQKTKGHR | 10319 | 36434 | 1.137 | 0.014 |