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Table 1 Beneficial and non-beneficial OLP identified in Lima clade B cohort (p < 0.05)

From: Definition of the viral targets of protective HIV-1-specific T cell responses

OLP # Protein Sub-unit OLP clade B
consensus
sequence
Median viral
load in OLP
responders
Median viral
load in OLP
non-responders
Protective Ratio
(PR)*
p-value
3 Gag p17 EKIRLRPGGKKKYKLKHI 22947 39014 1.053 0.037
6 Gag p17 ASRELERFAVNPGLL 15380 43189 1.107 0.001
7 Gag p17 ERFAVNPGLLETSEGCR 25939 38974 1.040 0.049
10 Gag p17 QLQPSLQTGSEELRSLY 16285 37237 1.085 0.031
12 Gag p17 SLYNTVATLYCVHQRIEV 23855 37113 1.044 0.037
23 Gag p24 AFSPEVIPMFSALSEGA 22947 37113 1.048 0.036
31 Gag p24 IAPGQMREPRGSDIA 3563 35483 1.281 0.028
34 Gag p24 STLQEQIGWMTNNPPIPV 6127 37360 1.207 0.002
48 Gag p24 ACQGVGGPGHKARVLAEA 12975 35755 1.107 0.041
60 Gag p15 GKIWPSHKGRPGNFLQSR 16266 36434 1.083 0.044
75 Nef - WLEAQEEEEVGFPVRPQV 13407 37360 1.108 0.026
76 Nef - EVGFPVRPQVPLRPMTYK 59618 29855 0.937 0.001
84 Nef - NYTPGPGIRYPLTFGWCF 55402 30538 0.945 0.006
85 Nef - RYPLTFGWCFKLVPV 69890 29903 0.924 0.002
90 Nef - SLHGMDDPEKEVLVWKF 89687 32650 0.911 0.042
159 Pol Pro KMIGGIGGFIKVRQYDQI 14736 36434 1.094 0.020
160 Pol Pro FIKVRQYDQILIEICGHK 3682 35755 1.277 0.031
161 Pol Pro QILIEICGHKAIGTVLV 9117 35483 1.149 0.050
163 Pol Pro LVGPTPVNIIGRNLLTQI 25965 45637 1.055 0.007
171 Pol RT LVEICTEMEKEGKISKI 1865 35483 1.391 0.014
181 Pol RT LDVGDAYFSVPLDKDFRK 65858 32871 0.937 0.041
195 Pol RT LRWGFTTPDKKHQKEPPF 5624 37113 1.219 0.006
196 Pol RT DKKHQKEPPFLWMGYELH 10103 35483 1.136 0.044
210 Pol RT EIQKQGQGQWTYQIY 18155 35483 1.068 0.045
222 Pol RT PPLVKLWYQLEKEPIVGA 412599 34640 0.808 0.030
230 Pol RT IHLALQDSGLEVNIV 85102 34117 0.919 0.030
237 Pol RT VYLAWVPAHKGIGGNEQV 85102 34117 0.919 0.029
240 Pol RT SAGIRKVLFLDGIDKA 116902 32761 0.891 0.019
269 Pol Int TKELQKQITKIQNFRVYY 6629 35755 1.192 0.030
270 Pol Int TKIQNFRVYYRDSRDPLW 18171 37360 1.073 0.019
271 Pol Int YYRDSRDPLWKGPAKLLW 25939 35755 1.032 0.043
276 Pol Int KIIRDYGKQMAGDDCVA 6629 35755 1.192 0.021
279 Vpr - GPQREPYNEWTLELLEEL 60222 32650 0.944 0.042
307 Env Gp120 DLNNNTNTTSSSGEKMEK 179419 34117 0.863 0.044
311 Env Gp120 IRDKVQKEYALFYKLDVV 179419 32871 0.860 0.008
314 Env Gp120 YRLISCNTSVITQACPKV 58206 31273 0.943 0.008
315 Env Gp120 SVITQACPKVSFEPIPIH 61011 32871 0.944 0.034
320 Env Gp120 TNVSTVQCTHGIRPVV 341587 34640 0.820 0.034
355 Env Gp120 VAPTKAKRRVVQREKRAV 161602 34117 0.870 0.042
399 Env Gp41 VIEVVQRACRAILHIPRR 388089 34640 0.812 0.026
405 Vif - VKHHMYISGKAKGWFYRH 16458 37237 1.084 0.021
406 Vif - GKAKGWFYRHHYESTHPR 16458 37237 1.084 0.022
424 Vif - TKLTEDRWNKPQKTKGHR 10319 36434 1.137 0.014
  1. * PR values in bold indicate PR > 1, i.e. OLP-responses seen more frequently in individuals with reduced viral loads