Skip to main content

Table 6 Prediction of clinical activity status by genotype at each of 19 genetic polymorphisms: all response-evaluable patients with genetic polymorphism data and status = benefit or non-benefit.

From: A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma

Gene Polymorphism N DF P-value OR: Genotype
1/2 vs 1/1
OR: Genotype
2/2 vs 1/1
      Estimate 95% CI Estimate 95% CI
BTNL2 rs2076530 56 2 0.48 0.40 0.08, 1.93 0.81 0.12, 5.25
CCR5 CCR5d32 57 2 0.54 0.41 0.04, 3.83 0.00 0.00, Inf
CCR5 rs1799987 57 2 0.80 0.76 0.17, 3.39 1.35 0.25, 7.35
CD86 rs1129055 57 2 0.11 1.92 0.50, 7.38 0.00 0.00, Inf
CD86 rs2681417 55 1 0.52 2.39 0.18, 31.0 NA NA, NA
CTLA4 rs11571317 57 1 0.78 0.73 0.07, 7.25 NA NA, NA
CTLA4 rs1863800 55 2 0.06 0.35 0.08, 1.45 0.00 0.00, Inf
CTLA4 rs231775 56 2 0.05 0.43 0.07, 2.73 3.75 0.72, 19.42
CTLA4 rs3087243 55 2 0.07 0.39 0.09, 1.62 0.00 0.00, Inf
CTLA4 rs4553808 56 2 0.08 0.19 0.02, 1.76 3.25 0.37, 28.28
IFNAR1 rs2257167 57 2 0.98 0.93 0.23, 3.80 1.24 0.10, 14.60
IFNAR2 rs7279064 57 2 0.59 0.83 0.22, 3.15 0.00 0.00, Inf
IFNG rs2069705 57 2 0.79 0.71 0.18, 2.82 0.50 0.05, 5.31
IFNG rs2430561 56 2 0.67 1.22 0.20, 7.31 2.36 0.30, 18.72
IL23R rs1004819 57 2 0.95 0.81 0.19, 3.37 0.97 0.14, 6.52
IL23R rs11209026 57 1 0.40 0.42 0.05, 3.93 NA NA, NA
IL23R rs2201841 56 2 0.82 0.64 0.15, 2.65 0.80 0.07, 9.43
IL23R rs7517847 56 2 0.35 2.33 0.50, 10.85 0.67 0.06, 7.77
PTPN22 rs2476601 57 1 0.95 0.93 0.09, 9.69 NA NA, NA
  1. 1/1 = major-allele homozygote; 1/2 = heterozygote; 2/2 = minor-allele homozygote.
  2. CI = Confidence Interval.
  3. DF = degrees of freedom for likelihood-ratio test (LRT).
  4. Inf = infinite.
  5. N = number of patients with non-missing genotypes.
  6. OR = odds ratio comparing the odds of Status = Benefit between two genotype classes. OR > 1 means that the odds of Benefit were greater for class 1/2 or 2/2 than for class 1/1.
  7. NA = not estimable.
  8. P-value is for a logistic regression LRT of whether both (if > 1 estimable) odds ratios = 1.