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Table 2 IAA levels greater than the 60th percentile predict T1D by 20 weeks

From: Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

 

7 wk

8.5 wk

10 wk

 

Diabetic by 20 wk

 

Diabetic by 20 wk

 

Diabetic by 20 wk

 
 

(+)

(-)

Total

(+)

(-)

Total

(+)

(-)

Total

IAA > Threshold (+)

17

5

22

20

3

23

18

2

20

IAA < Threshold (-)

8

24

32

5

26

31

7

25

32

Total

25

29

54

25

29

54

25

27

52

Sensitivity

  

0.68

  

0.80

  

0.72

Specificity

  

0.83

  

0.90

  

0.93

Positive Predictive Value

  

0.77

  

0.87

  

0.90

Negative Predictive Value

  

0.75

  

0.84

  

0.78

  1. The thresholds for a positive (+) predictive IAA measurement were chosen as the 60th percentile in the NOD mice of the specified age. Displayed in each column are numbers of mice that do (+) or do not (-) develop diabetes by 20 weeks of age and had IAA values greater (+) or less (-) than the threshold. IAA thresholds for 7, 8.5, and 10 week old mice are 47, 100, and 252, respectively. Mice not tested at the specified age were considered to have a positive predictive IAA level if the IAA values were greater than the threshold on the week prior and following the specified age.