Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

Table 1 IAA levels over a threshold calculated by ROC analyses predict T1D by 20 weeks

The thresholds for a positive (+) predictive IAA measurement were chosen based on IAA values with the maximum likelihood ratio calculated from the ROC analyses for the NOD mice at 7, 8-8.5, and 10 weeks of age. The number of mice that do (+) or do not (-) develop diabetes by 20 weeks of age and had IAA values greater (+) or less (-) than the threshold are displayed in each column. The IAA threshold for mice at 7, 8.5, and 10 weeks are 176, 115, and 190, respectively. Mice not tested at the specified age were considered to have a positive predictive IAA level if the IAA values were greater than the threshold on the week prior and following the specified age.

ISSN: 1479-5876