Figure 6From: Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes statusIAA levels measured at 8-10 weeks of age can distinguish mice progressing to disease. Positive predictive IAA thresholds for each age were calculated as in Table 1 and are indicated by the dotted lines. IAA values measured at 7, 8-8.5, and 10 weeks of age are shown for each mouse that did (Db+) or did not (Db-) become diabetic by 20 weeks. IAA value is calculated as the average signal from triplicate wells divided by the background signal from triplicate wells with negative control sera.Back to article page