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Figure 9 | Journal of Translational Medicine

Figure 9

From: Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer

Figure 9

STEAP 281-296 -reactive CD4 T-cell recognize naturally processed exogenous antigen presented by autologous DCs. STEAP281-296-reactive CD4 T-cell clones SH31 (A), SH6 (B), and Sa12 (C) were tested for their reactivity against STEAP positive LC cell (LU65, A549, and RERF-LC-AI) lysates and STEAP negative Jurkat cell lysate when presented by autologous DCs. The capacity of L243 to inhibit these responses was assessed to demonstrate that T-cell reactivity was through TCR/HLA interactions. Columns means of triplicate determinations, bars SD. Columns without bars had SD < 10% the values of the mean. Results are representative of at two separate experiments.

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