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Figure 10 | Journal of Translational Medicine

Figure 10

From: Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer

Figure 10

Assessment of cytolytic activity of STEAP 281-296 - or EZH2 95-109 -reactive CD4 T-cell clones. The DR15-restricted, STEAP281-296-reactive CD4 T-cell clone SH31 (A, left), and DR53-restricted, STEAP281-296-reactive CD4 T-cell clone Sa12 (A, right) were evaluated for their capacity to kill STEAP-expressing, DR53 positive LC cells (LU65 and Calu-1) or STEAP-expressing, DR53 negative LC cells (EBC1, negative control). The DR15-restricted, EZH295-109-reactive CD4 T-cell clones SK32 (B, left), Sa361 (B, middle), and DR53-restricted, EZH295-109-reactive CD4 T-cell clone Sa362 (B, right) were evaluated for their capacity to kill EZH2-expressing, DR15 positive LC cells (LU65 and RERF-LC-AI), DR53 positive LC cells (LU65 and Calu-1) or EZH2-expressing, DR15 and DR53 negative LC cells (EBC1, negative control). Points means of triplicate determinations, bars SD. Points without bars had SD < 10% the value of the mean.

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