Cellular ATP concentrations in response to chemotherapy . HCT116 cells were treated as indicated  to produce cells with low (G-cells), medium (M-cells) and high (SM-cells) bioenergetic signature. Cells were then treated with the following agents: 8 μM 3BrP, 100 μM IA, 10 μM 5-FU or left untreated (Control) and ATP concentrations were determined. Histograms shown are means ± SEM. *, p < 0.05 compared to controls by Student's t test. ns, no significant.