Figure 5

Identification of EBV LMP1 and LMP2 epitope-specific CD8⁺ T cells and Tcregs in NPC. (A) CD8⁺ T cells and Tcregs specific for the HLA-A2-restricted EBV epitopes LLW and YLQ (LMP1) and GLG (LMP2) in PBMCs and TILs were evaluated by FACS after staining for CD8, Foxp3, and tetramer. The results shown are from one patient. (B) The frequency of CD8⁺ tetramer⁺ T cells and CD8⁺ Foxp3⁺ tetramer⁺ T cells in PBMCs and TILs. The results shown represent the mean ± SE of 12 PBMCs and 6 TILs from HLA-A2-positive patients with NPC. *P < 0.05 compared with TILs.