Figure 2From: Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinomaDistribution of Tcregs and Tc17 cells in PBMCs and TILs from paired NPC patients. The proportion of Tcregs (A, B) and Tc17 cells (C, D) in total CD8+ T cells from PBMCs and freshly isolated TILs of paired NPC patients (n = 21) and healthy donors (HD, n = 21). Subsets were identified by intracellular staining of Foxp3 and IL-17 after PMA/ionomycin stimulation in vitro. Cumulative data show a significant increase in the number of Tcregs in PBMCs and TILs of NPC patients as compared with PBMCs of healthy donors and a significant decrease in Tc17 cells from PBMCs of NPC patients as compared with TILs from NPC patients and PBMCs from healthy donors.Back to article page