Figure 4

MicroCT imaging of patient-derived intra-femoral (IF) PCSD1 xenografts revealed mixed osteolytic and osteoblastic bone lesions. MicroCT scanning was performed on femurs and tibia isolated from mice injected with primary patient-derived tumor in the right femur showed that areas of increased bone density and sclerosis were apparent in the femur in which the tumor was growing as shown above for mouse IF15. A. P0 Bones osteolytic/osteoblastic microCT images. B. 3D reconstruction of distal femur.