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Table 3 Chemotherapy and concomitant medications by treatment group

From: Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study

 

Nadroparin (n = 769) % (n)

Placebo (n = 381) % (n)

P-value (two tailed)

Chemotherapy regimen containinga:

   5-Fluorouracil

37.1 (285)

39.6 (151)

0.40

   Cisplatin

23.0 (177)

22.6 (86)

0.87

   Gemcitabine

20.3 (156)

22.6 (86)

0.37

   Oxaliplatin

18.6 (143)

23.4 (89)

0.06

   Docetaxel

18.5 (142)

17.6 (67)

0.72

   Carboplatin

15.5 (119)

14.4 (55)

0.64

   Irinotecan

12.5 (96)

10.8 (41)

0.40

   Vinca alkaloids

11.7 (90)

7.1 (27)

0.01

   Capecitabine

7.9 (61)

7.9 (30)

0.97

   Epirubicin

7.0 (54)

6.3 (24)

0.65

   Etoposide

5.3 (41)

4.5 (17)

0.53

   Cyclophosphamide

4.3 (33)

4.7 (18)

0.74

   Liposomal doxorubicin

3.8 (29)

2.9 (11)

0.44

   Adriamycin

3.3 (25)

5.0 (19)

0.15

   Trastuzumab

3.0 (23)

2.4 (9)

0.54

   Cetuximab

0.9 (7)

0.8 (3)

0.83

   Bevacizumab

0.5 (4)

0.5 (2)

0.99

Concomitant Medication b

   Steroids

76.2 (586)

78.7 (300)

0.34

   G-CSF

15.1 (116)

15.5 (59)

0.86

   NSAID

11.2 (86)

12.9 (49)

0.41

   Erythropoietin

7.4 (57)

8.7 (33)

0.46

   Blood and related products

2.7 (21)

3.9 (15)

0.27

   Aspirin

2.2 (17)

2.1 (8)

0.90

  1. aThe most used antineoplastic drugs (≥ 1%) are reported in the table; the sum is not 100% of study population; bConcomitant medications that could potentially interact with coagulation factors; the sum is not 100% of study population
  2. Abbreviation: G-CSF, Granulocyte colony-stimulating factor; NSAID, Nonsteroidal anti-inflammatory drugs