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Table 1 Key genes associated with acute allograft rejection according to human microarray studies

From: Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis

Author: Tannapfel et al. 2001[14]

Organ: Liver

IL3

MMP9

TGF-B1-3

TIMP1

TNF

CLUSTERIN (CLU)

IL10

   

Author: Sreekumar et al. 2002[15]

Organ: Liver

C1QB

C3

LIPC

GZMB

HSPA1A

IGF1

IL2

(IRF9*)

STAT1

ACADM

HLA-I

HLA-II

PCK1

SELPLG

TGFB1

TNF

TNFAIP3

TNFSF10

UBB3#

UBA1

UBE2N

ADAM17

GYS2

CTPS

      

Inkinen et al. 2005[16]

Organ: Liver

HLA-D

IL2RB

IL2RG

CASP1

CASP3

GZMA

GZMB

SELL

ICAM3

ITGA4

SELE

VCAM1

IFNG

IL1B

      

Asaoka et al. 2009[28]

Organ: Liver

AKAP11

ALOX15

CASP8

CFLAR

FFAR3

IFNAR1

IGFBP3

IL12RB1

LTA

POU4F1

PPP1R8

PPP1R3A

PVRL1

TNK2

      

Author: Gimino et al. 2003[17]Lande et al. 2006[30](MINNEAPOLIS Dataset)

Organ: Lung

C4B

CCR7

CD28

CD3E

CD84

CTLA4

CXCR3

GZMK

GZMA

IFNG

IGKC

ITK

KIR

PRF1

STAT4

IL2RA

IL2RB

Zap70

LCK

 

Patil et al. 2008 (MINNEAPOLIS2 Dataset)[18]

Organ: Lung

IFITM1

CD8A

MARCKS

CCL3

GZMB

ITM2A

IL32

IL8

CCL4

 

Author: Karason et al. 2006[19]

Organ: Heart

C3

C4A

CXCL9

CXCL10

GBP1

HLA-C

HLA-F

HLA-J

IGFBP4

NPPA

PSME2

RARRES3

STAT1

       

Author: Akalin et al. 2001[21]

Organ: Kidney

Humig

(CXCL9)

C3

CD18

(ITGB2)

ISGF-3

(STAT1)

MCL1

MIP-3β

(CCL19)

NNMT

RING4

(TAP1)

TCRB #

IL2-SP 2#

(LCP1)

Author: Sarwal et al. 2003 (STANFORD Dataset)[22]

Organ: Kidney

HLA-A

HLA-B

HLA-C

HLA-E

HLA-DR

HLA-DQ

HLA-DMA

HLA-DRB4

TGFBR2

TGFR1

TCR

DARC

C4B

CXCL9

SCYA3

(CCL3)

SCYA5

(CCL5)

CCR5

SCYA2

(CCL2)

CD20

PERFORIN

CD53

NFKB1

NK4 (IL32)

CX3CR1

GZMA

STK17B

IL6R

IL2RB

IL15RA

IL16

STAT1

CASP10

IFNGR1

IGHG3

IGKC

IGL

IGHM

LENG4

CD59

VCAM1

CXCL9

CXCL10

CCR5

       

Author: Flechner et al. 2004 (CLEVELAND Dataset)[23]

Organ: Kidney

C1QB

CCL5

CD14

CD163

TRB@

CD16

CD2

CD27

CD3D

CD48

CD53

CD64 (FCGR1A)

CD8

CDW52

CXCR4

GZMA

HLA-F

IFI30

IL10RA

IL10RB

IL4R

ISG20

PKR

(PRKRA)

RAGE4 (RAGE)

TNFRSF1b

     

Reeve et al. 2009 (EDMONTON Dataset)[24]

Organ: Kidney

APOBEC3G

CCL4

CCL5

CD8A

CRTAM

CXCL9

CXCL10

CXCL11

FAM26F

GBP1

GBP2

GBP4

GBP5

GZMA

GZMB

INDO

LCP2

LILRB1

NLRC5

PSMB9

Author: Morgun et al. 2006 (SAN PAULO Dataset)[25]

Organ: Heart + Lung + Kidney

(SAN PAULO+ MINNEAPOLIS+STANFORD+CLEVELAND Datasets)

ABCA7

CD14

DAP10

HLA-A

HSD17B7

ISG20

LEF1

NT5C2

RU2

TRAF2

ADAM15

CD2

F2R

HLA-B

HSPC043

ISGF3G (IRF9)

LIAS

PAK4

SELPLG

TRB@

ADAM8

CD3Z

FCER1G

HLA-DMA

HSPC129

ITGB2

LILRB4

PCDHGA8

SLC14A2

UBD

B2M

CD53

FKBP14

HLA-DMB

IFI30

KCNJ5

LOC90586

PSCD4

SMG1

UBE1L

BAX

CD7

FLJ10244

HLA-DQB1

IGHG3

KCNK6

LOC92033

PSMB9

SORL1

UBE2B

BTN3A3

CD74

FLJ11106

HLA-DRA

IGKC

KIAA0924

LTB

PSME1

STAT1

UBE2L6

C1QA

CG012

FLJ11151

HLA-DRB1

IGLC2

KIAA1030

LTB4R

RAB7L1

SULT1A3

UCP2

C4A

CHD3

FLJ11467

HLA-DRB3

IGLC6

KIAA1170

MAFF

RAC2

TAP1

WSX1 (IL27RA)

CASP4

CORO1A

FY

HLA-DRB5

IGLJ3

KIAA1257

MSH3

RARRES3

TAPBP

ZAP70

CCL18

CTSS

GMFG

HLA-E

IL2RB

KIAA1348

NKG7

RASGRP2

TCBRV (IL23A)

ZNRD1

CCL5

CX3CL1

GZMK

HLA-F

IRF3

LAT

NM23-H6

RBL1

TNFAIP3

TNFSF13B

CXCL9

D21S2056E

HA-1

HLA-G

IRF5

LCK

NPHP1

RIMS1

  

Reference: Saint-Mezard et al. 2008 (PARIS Dataset)[26]

Organ: Kidney

(PARIS+STANFORD+CLEVELAND+NON HUMAN PRIMATES Datasets)

ARHGDIB

ARPC2

CASP1

CASP4

CCL5

CD163

CD44

CD48

CD52

CD53

CD8A

CSPG2

CXCL10

CXCL9

FCER1G

FER1L3

GBP1

GBP2

GMFG

GZMA

HCK

HCLS1

HLA-B

HLA-C

HLA-DMA

HLA-DMB

HLA-DPA1

HLA-DQB1

HLA-DQB2

HLA-DRA

HLA-DRB3

HLA-E

HLA-F

HLA-G

IFI30

IFITM1

IGHM

IL10RA

ISG20

ITGB2

LAPTM5

LCK

LCP1

LCP2

LTF

LYZ

MMP7

NMI

PLEK

PLSCR1

PRG1

PRKCB1

PSMB10

PSMB8

PSMB9

RAC2

RUNX3

SERPING1

SLA

STAT1

TAP1

TCIRG1

TIMP1

TNC

TNFRSF7

UBD

UBE2L6

WARS

WFDC2

T3JAM (TRAF3IP3)

Rodder et al. 2010 (TENON/INSELSPITAL Dataset)[29]

Organ: Kidney

Meta-analysis focused on metzincins and related genes

(TENON/INSELSPITAL+EDMONTON+STANFORD+ CLEVELAND Datasets)

TIMP1

MMP7

ADAMTS18

ADAMTS6

ADAMTS17

ADAMTS8

ADAMTSL4

ADAM18

TLL2

ADAM17

PLG

LAMA4

EMILIN2

       

Chen et al. 2010 (STANFORD2 dataset)[27]

Organs: Kidney, Heart

(STANFORD2+CLEVELAND+SAN PAULO Datasets)

CXCL9

CXCL11

CXCR4

STAT1

CCL4

C6orf32

MARCKS

IGSF6

CD2

TRPM1

IL10RA

RARRES3

NR4A2

PTPRC

LEF1

TAP1

CTSS

ISG20

CCL8

BASP1

SLC2A3

LCP2

HLA-DMA

BIRC5

HLA-DMB

CASP4

SELL

HLA-F

CD44

HLA-DQB1

PIK3CD

PECAM1

MDK

MELK

CDKN3

CPD

SH2D2A

CCNB2

HLA-DRA

B2M

DIAPH1

USP34

SCAND2

RUNX1

S100A4

     
  1. Genes underlining highly redundant themes among studies are in bold.
  2. This table reports upregulated genes associated with acute allograft rejection detected by microarrays technology analyzing human graft samples (bronchoalveolar lavage for lung samples, tissue biopsies for the other samples). Additional detail regarding the data extraction is provided in Additional file 1.
  3. *Synonymous gene symbols, according to NCBI Gene, are provided in brackets.
  4. #The original name reported in the publication was: TCR Active β-chain related gene (M12886: unmapped). 2# The original name reported in the publication was: IL-2-stimulated phosphoprotein. 3#The original name reported in the publication was: ubiquitin.