First 5 Immune networks according to Ingenuity Pathways Analysis (IPA), representing schematic relationships among key genes upregulated in acute allograft rejection (Network number 1 (A), 2 (B), 3 (C), 4 (D) and 7(E), generated by IPA). The gene list uploaded represents the key gene list (Table 1). Red: The genes and gene complexes from the key gene list are represented in red background (no color fill is used for the genes that are part of the network but not part of the key gene list). Blue: IFN-γ stimulated genes (designated IFN-γ stimulated genes identified as those upregulated in peripheral monocytes after IFN-γ stimulation). A. the first network is centered around IFN-γ; B. the second network is centered around TNF- α; C. the third network focuses on Interferon Regulatory Factors (IRFs) and chemokine/chemokine receptor interaction (i.e., CCR5/CCR5 ligands and CXCR3/CXCR3 ligands); D. the fourth network focuses on Immune Effector Function (IEF) genes (i.e., around granzyme B, perforin, caspases); E. the fifth network is centered around the NF-kB complex. Bold lines indicate direct interaction. Dotted lines indicate indirect interaction.