EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma

Table 1 Patients' age, gender, tumor staging, frequencies of EGFR-specific T cells ^a and EGFR score ^b

No	Age (yrs)	TNM	EGFR score	KLF (%)	YLN (%)
1	76	T4 N0 M0	1	0.0029	0.0027
2	84	T3 N1 MX	2	0.0125	0.0084
3	59	T4 N0 MX	2	0.0034	0.0074
4	61	T1 N0 MX	4	0.0050	0.0143
5	55	T2 N0 MX	4	0.0145	0.0193
6	56	T3 N2b M0	4	0.0216	0.0164
7	83	T2 N0 MX	4	0.0107	0.0241
8	67	T1 N0 M0	4	0.0069	0.0061
9	41	T2 N2a MX	4	0.0089	0.0045
10	68	T3 N2 M0	6	0.0062	0.0045
11	55	T2 N2 MX	6	0.0134	0.0145
	64.1		3.7	0.015 ± 0.001	0.014 ± 0.002
12	58	T3 N1 M0	9	0.0265	0.0758
13	52	T4 N2b M0	9	0.0351	0.0387
14	64	T3 N1 M0	12	0.0218	0.0097
15	60	T3 N0 MX	12	0.0409	0.0549
16	62	T2 N2a MX	12	0.0234	0.0748
	59.2		10.8	0.029 ± 0.008	0.051 ± 0.028

a - The frequency of EGFR-specific T cells in PBMC are shown for KLF (pentamer) and YLN (tetramer) peptides in percent (%) of CD8 positive T cells in HNSCC patients with low EGFR score (2-6) and high EGFR score (9-12). All mean values are printed in bold for each patient group.
b - EGFR scores were calculated as staining intensity (1-4) multiplied by the number of EGFR-positive cells (0-4) determined by immunohistochemistry.

ISSN: 1479-5876