|
No
|
Age (yrs)
|
TNM
|
EGFR score
|
KLF (%)
|
YLN (%)
|
|---|
|
1
|
76
|
T4 N0 M0
|
1
|
0.0029
|
0.0027
|
|
2
|
84
|
T3 N1 MX
|
2
|
0.0125
|
0.0084
|
|
3
|
59
|
T4 N0 MX
|
2
|
0.0034
|
0.0074
|
|
4
|
61
|
T1 N0 MX
|
4
|
0.0050
|
0.0143
|
|
5
|
55
|
T2 N0 MX
|
4
|
0.0145
|
0.0193
|
|
6
|
56
|
T3 N2b M0
|
4
|
0.0216
|
0.0164
|
|
7
|
83
|
T2 N0 MX
|
4
|
0.0107
|
0.0241
|
|
8
|
67
|
T1 N0 M0
|
4
|
0.0069
|
0.0061
|
|
9
|
41
|
T2 N2a MX
|
4
|
0.0089
|
0.0045
|
|
10
|
68
|
T3 N2 M0
|
6
|
0.0062
|
0.0045
|
|
11
|
55
|
T2 N2 MX
|
6
|
0.0134
|
0.0145
|
| |
64.1
| |
3.7
|
0.015 ± 0.001
|
0.014 ± 0.002
|
|
12
|
58
|
T3 N1 M0
|
9
|
0.0265
|
0.0758
|
|
13
|
52
|
T4 N2b M0
|
9
|
0.0351
|
0.0387
|
|
14
|
64
|
T3 N1 M0
|
12
|
0.0218
|
0.0097
|
|
15
|
60
|
T3 N0 MX
|
12
|
0.0409
|
0.0549
|
|
16
|
62
|
T2 N2a MX
|
12
|
0.0234
|
0.0748
|
| |
59.2
| |
10.8
|
0.029 ± 0.008
|
0.051 ± 0.028
|
- a - The frequency of EGFR-specific T cells in PBMC are shown for KLF (pentamer) and YLN (tetramer) peptides in percent (%) of CD8 positive T cells in HNSCC patients with low EGFR score (2-6) and high EGFR score (9-12). All mean values are printed in bold for each patient group.
- b - EGFR scores were calculated as staining intensity (1-4) multiplied by the number of EGFR-positive cells (0-4) determined by immunohistochemistry.
