Table 2 Univariate prognostic analysis of overall survival and disease-free survival in HCC patients
From: Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma
Variable | Overall survival rate (%) | Disease-free survival rate (%) | ||||
|---|---|---|---|---|---|---|
| Â | 3 y | 5 y | P value | 3 y | 5 y | P value |
Gender | Â | Â | Â | Â | Â | Â |
   Female (n = 12) | 91.3 | 61.8 | 0.328 | 66.7 | 66.7 | 0.176 |
   Male (n = 116) | 61.9 | 51.0 |  | 43.8 | 43.8 |  |
Age (years) | Â | Â | Â | Â | Â | Â |
   ≤ 50 (n = 65) | 62.5 | 52.2 | 0.567 | 42.7 | 42.7 | 0.101 |
   > 50 (n = 63) | 67.0 | 51.9 |  | 49.4 | 49.4 |  |
HBsAg status | Â | Â | Â | Â | Â | Â |
   Negative (n = 18) | 88.5 | 62.1 | 0.122 | 71.8 | 71.8 | 0.027 |
   Positive (n = 110) | 60.5 | 49.7 |  | 41.9 | 41.9 |  |
AFP (μg/l) |  |  |  |  |  |  |
   ≤ 400 (n = 78) | 59.3 | 47.7 | 0.219 | 44.3 | 44.3 | 0.555 |
   > 400 (n = 50) | 75.0 | 59.8 |  | 50.9 | 50.9 |  |
Cirrhosis | Â | Â | Â | Â | Â | Â |
   No (n = 13) | 91.7 | 80.2 | 0.053 | 54.9 | 54.9 | 0.184 |
   Yes (n = 115) | 61.3 | 48.1 |  | 44.6 | 44.6 |  |
Child-Pugh classification | Â | Â | Â | Â | Â | |
   A (n = 116) | 65.4 | 55.0 | 0.378 | 48.8 | 48.8 | 0.154 |
   B (n = 12) | 58.3 | 29.2 |  | 20.8 | 20.8 |  |
Tumour size (cm) | Â | Â | Â | Â | Â | Â |
   ≤ 5 (n = 50) | 81.7 | 77.3 | < 0.001 | 72.1 | 72.1 | < 0.001 |
   > 5 (n = 78) | 52.6 | 36.3 |  | 29.2 | 29.2 |  |
Multiple tumours | Â | Â | Â | Â | Â | Â |
   No (n = 91) | 70.0 | 60.4 | 0.002 | 56.5 | 56.5 | < 0.001 |
   Yes (n = 37) | 49.3 | 30.2 |  | 19.8 | 19.8 |  |
Tumour capsule | Â | Â | Â | Â | Â | Â |
   Complete (n = 32) | 71.2 | 71.2 | 0.165 | 61.1 | 61.1 | 0.096 |
   No/incomplete (n = 96) | 62.5 | 46.4 |  | 41.0 | 41.0 |  |
Vascular invasion | Â | Â | Â | Â | Â | Â |
   No (n = 98) | 71.7 | 65.3 | < 0.001 | 54.2 | 54.2 | < 0.001 |
   Yes (n = 30) | 40.8 | 11.6 |  | 19.4 | 19.4 |  |
TNM stage | Â | Â | Â | Â | Â | Â |
   I (n = 67) | 79.3 | 72.1 | < 0.001 | 64.7 | 64.7 | < 0.001 |
   II (n = 30) | 54.9 | 38.4 |  | 30.8 | 30.8 |  |
   III (n = 31) | 42.0 | 22.5 |  | 20.7 | 20.7 |  |
Edmondson-Steiner grade | Â | Â | Â | Â | Â | |
   I/II (n = 69) | 75.9 | 63.0 | 0.004 | 56.7 | 56.7 | 0.003 |
   III/IV (n = 59) | 50.6 | 38.4 |  | 33.4 | 33.4 |  |
MACC1 expression level | Â | Â | Â | Â | Â | |
   Low (n = 71) | 73.5 | 61.9 | 0.003 | 54.5 | 54.5 | 0.008 |
   High (n = 57) | 51.8 | 37.6 |  | 33.5 | 33.5 |  |