Figure 4
Virus growth in GI-101A tumor xenografts positively correlates with v irus yields in cell cultures. (A) Viral titers in the GI-101A tumors. Nude mice bearing the GI-101A tumors were injected i.v. with each virus strain at 5 × 106 pfu/mouse. Tumors were harvested at 14 days post virus administration. The values are the mean of quadruplicate samples, and the bars indicate SD. Statistical analysis was performed using unpaired t test with Welch's correction. * indicates P < 0.05, when compared with the GLV-1h68 group. (B) Correlation between virus yields in the GI-101A cell culture (48 hpi, MOI 0.01) and virus growth in the GI-101A tumors.