Table 2 Ontological clustering of genes exhibiting altered expression according to DAVID
Cluster | Enrichment score | No of genes | Annotated genes | Gene ontology |
|---|---|---|---|---|
1 | 7,52 | 5 | KRR1, NOC2L, INTS6,UTP20,YPEL3 | nuclear lumen, nucleolus |
2 | 5,02 | 7 | DLG7, NUSAP1, ZWINT, TPX2, HCAP-G, CEP164, CDCA5 | nuclear division, M phase of mitotic cell cycle sister chromatid segregation nucleus |
3 | 4,99 | 12 | CUGBP2, SRP46, RNPC2, HNRPL, THOC4, SNRPA1, PRPF40A, HNRPM, RSRC1, SRRM1, TRA2A, U2AF1 | mRNA processing, mRNA metabolic process |
4 | 4,37 | 5 | PBK, KIF11, AURKA, KIF15, TPX2 | nuclear division, M phase of mitotic cell cycle, ATP binding, phosphoprotein |
5 | 3,68 | 8 | CHD9, ASCC3L1, DDX51, PXK, EIF4A1, MCM4, LGP2, DDX24 | helicase activity, nucleotide phosphate-binding region:ATP |
6 | 3,37 | 16 | CDC2, UHMK1, PBK, CSNK1A1, RIPK5, BUB1B, AURKA, CAMKK2, BUB1, PMSF1, MAP3K1, PSMD7, CCNB1, UBE2C, CAMK1D, CDC20 | protein serine/threonine kinase activity cell cycle process, atp-binding |
7 | 2,89 | 5 | ZNF148, TCF25, TCF4, CSDA, ZNF281 | negative regulation of transcription from RNA polymerase II promoter, negative regulation of RNA metabolic process negative regulation of cellular biosynthetic process, transcription factor activity nucleus, phosphoprotein |
8 | 2,41 | 9 | C13orf10, ZMYM4, ZC3H12C, ZCCHC2, SMYD4, RFWD3, BIRC4BP, ZC3H11A, KIAA0182 | zinc-finger transition metal ion binding |
9 | 1,94 | 7 | CHD9, ASCC3L1, DDX51, PXK, EIF4A1, MCM4, LGP2, DDX24 | cytoskeleton ATP binding intracellular non-membrane-bounded organelle |
10 | 1,92 | 5 | WDR61, SLC25A32, TP53, FBXW7, DTL | wd repeat |