Figure 3
Top ranked networks identified by IPA. IPA networks that depict associations between genes involved in certain biological functions: (a) Gene Expression, Cellular Development, Hematological System Development and Function (score 38), (b) Cell Cycle, Cancer, Genetic Disorder (score 36), (c) Cellular Growth and Proliferation, Lipid Metabolism, Nucleic Acid Metabolism (score 35), (d) Genetic Disorder, Metabolic Disease, Antimicrobial Response (score 32). The network is graphically displayed with genes/gene products as nodes (different shapes that represent the functional class of the gene product, Figure 2) and the biological relationships between the nodes as edges (lines). The diagrams show direct (solid lines) and indirect (dashed lines) interactions between genes known to orchestrate common functions. The length of an edge reflects the evidence in the literature supporting that node-to-node relationship. Red and green shading denotes genes increased and decreased in expression, respectively, and the intensity of the colour indicates the degree of modulation. Molecules overlaid with orange and purple line are associated with immune response and HIV-1 infection, respectively. The score is derived from a p value and indicates the likelihood of the focus genes in a network to be found together due to random chance.