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Table 1 SPHK1 correlated with depth of tumor invasion and lymph node metastasis in esophageal carcinoma

From: An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma

Variables Score of SPHK1 expression P value
  0 1 2 3  
Age, year      0.374
Mean 61.7 61.2 63.2 60.1  
SD 11.0 12.8 11.9 14.3  
Gender      0.494
Male 7 11 15 26  
Female 11 6 17 31  
pT (primary tumor)      < 0.0001*
pT0 0 5 4 0  
pT1 1 2 6 6  
pT2 6 4 10 11  
pT3 11 6 12 40  
pN(lymphnode metastasis)      0.016*
pN0 14 10 16 17  
pN1 4 7 16 40  
   Differentiation      0. 737
high 4 15 9 19  
moderate 6 2 12 21  
low 8 0 11 17  
  1. Expression of SPHK1 protein was analyzed in 124 cases of esophageal squamous carcinoma. After staining, slides were evaluated by two pathologists. SPHK1 expression was determined by scoring intensity and percentage of cell staining. Tissues with no staining were rated as 0; those with faint staining or moderate to strong staining in < 25% of cells as 1; with moderate staining or strong staining in 25-50% of cells as 2; and with strong staining in > 50% of cells as 3. Statistical analysis indicated that in the esophageal carcinoma, SPHK1 expression was correlated with depth of tumor invasion (P < 0.0001) and lymph node metastasis (P = 0.016). There was no significant association with age, sex or tumor differentiation.