Figure 4
MCP-1 release from the human heart. In humans, MCP-1 is constitutively released from hearts with normal coronary arteries. However, following myocardial infarction, myocardial release of MCP-1 is reduced. This is the opposite pattern suggested from the murine mRNA studies. Furthermore, MCP-1 release is suppressed in all stages of coronary artery disease, suggesting that coronary artery disease, rather than the tissue damage from MI, is responsible for the suppression of MCP-1 release. Transmyocardial gradient = coronary sinus level - coronary artery level; stable = stable coronary artery disease; UAP = unstable angina pectoris; MI = myocardial infarction.