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Table 1 Immune cellular and molecular patters associated with outcome in cancer

From: An immunologic portrait of cancer

  T cell infiltrate STAT-1
IRF-1
T-bet+
IFN-γ
ISGs
GNLY
GZM
TIA
CXCL-9
CXCL-10
CXCL-11
CXCR3
CCL-5
CCR5
References*
Melanoma       
Better Survival +      [18, 19]
Response to ITx + + + + + [21, 26, 27, 30, 33]
Ovarian Cancer       
Better Survival +   + +   [4044, 7077, 83]
Colorectal Cancer       
Better Survival + + + + + [23, 4446, 4951, 53, 130]
Breast Cancer       
Response to CTx +    +   [54]
Better Survival + +     [24, 55, 81]
Lung/Bladder/Prostate/Cancer       
Better Survival +      [62, 63, 67]
Renal Cancer       
Better Survival +    +   [64]
Skin/Head and Neck/Anal Squamous Cell Carcinoma       
Better Survival + +   +   [65, 66, 68, 69]
Esophageal Cancer       
Suppression of tumor growth   +     [96]
Better survival +      [131]
  1. CTx chemotherapy; ISGs = Interferon stimulated genes; ITx = Immunotherapy
  2. The four categories of immune functions selected for this table summarize the most commonly observed transcriptional patterns associated with the immunologic constant of rejection [9, 10]
  3. *Manuscript s proposing at least one of the categories presented in the Table as a predictor of outcome; for more detail see text.