An immunologic portrait of cancer

Table 1 Immune cellular and molecular patters associated with outcome in cancer

	T cell infiltrate	STAT-1 IRF-1 T-bet⁺ IFN-γ ISGs	GNLY GZM TIA	CXCL-9 CXCL-10 CXCL-11 CXCR3	CCL-5 CCR5	References*
Melanoma
Better Survival	+					[18, 19]
Response to ITx	+	+	+	+	+	[21, 26, 27, 30, 33]
Ovarian Cancer
Better Survival	+		+	+		[40–44, 70–77, 83]
Colorectal Cancer
*Better Survival*	+	+	+	+	+	[23, 44–46, 49–51, 53, 130]
Breast Cancer
Response to CTx	+			+		[54]
Better Survival	+	+				[24, 55, 81]
Lung/Bladder/Prostate/Cancer
Better Survival	+					[62, 63, 67]
Renal Cancer
Better Survival	+			+		[64]
Skin/Head and Neck/Anal Squamous Cell Carcinoma
Better Survival	+	+		+		[65, 66, 68, 69]
Esophageal Cancer
Suppression of tumor growth		+				[96]
Better survival	+					[131]

CTx chemotherapy; ISGs = Interferon stimulated genes; ITx = Immunotherapy
The four categories of immune functions selected for this table summarize the most commonly observed transcriptional patterns associated with the immunologic constant of rejection [9, 10]
*Manuscript s proposing at least one of the categories presented in the Table as a predictor of outcome; for more detail see text.

ISSN: 1479-5876