Figure 2

Functional gene network analysis based on 349 genes derived from a Student's t test comparing relapse free and relapse patients affected by breast cancer [24]. Ingenuity pathway analysis of canonical pathways over-expressed in relapse free breast cancer patients compared to patients who did not relapse identified 46 pathways significantly affected. Immune function genes involved in interferon signaling associated with allograft rejection, autoimmune reaction, antigen presentation, B cell development and NK Cell Signaling ranked at the top and were up-regulated in lesions of breast cancer patients who endured a relapse-free survival.