Figure 1

Transcriptional profiling of 114 melanoma metastases; A) self organizing heat map displaying selected IRF-1 related transcripts together with the expression of MITF and melanoma differentiation antigens. Each column represents a melanoma metastasis. The dendrogram indicates the degree of similarity among genes (rows) or melanoma samples (columns) using Pearson's correlation coefficient. B) Matrix similarity based on Pearson correlation for the same genes. C) Self organizing map of IRF transcripts with related genes that have been observed to be expressed in tumors displaying better prognosis [23, 24, 45] and expressed during immune-mediated tissue-specific destruction [9, 10]. Highlighted is the IFN-γ/STAT-1/IRF-1/IL-15 cluster associated with a Th1 type of immune response. The yellow dashed lines underline the close relationship between the expression of IFN-γ and IRF-1 in the tumor microenvironment.