Table 2 Prevalence of the SNPs in the intron control region of the THRB gene in the NIH RTH cohort
SNP ID | Generalized RTH | Pituitary RTH | Odds ratio [CI] | p value | ||
|---|---|---|---|---|---|---|
Subjects | Sex | Subjects | Sex | |||
n = 34 | 16 M | n = 11 | 8 M | |||
18 F | 3 F | |||||
rs6798561 | n | % | n | % | ||
Genotype | ||||||
GG | 33 | 97.0 | 11 | 100 | ||
GA | 1 | 3 | 0 | 0 | n.a | n.a |
AA | 0 | 0 | 0 | 0 | ||
rs17194828 | n | % | n | % | CC vs. CA plus AA | |
Genotype | ||||||
CC | 28 | 82.3 | 7 | 63.6 | ||
CA | 6 | 17.6 | 4 | 36.4 | 2.7 [0.6 to 12.1] | 0.228 |
AA | 0 | 0 | 0 | 0 | ||
rs2596623 | n | % | n | % | CC vs. CT plus TT | |
Genotype | ||||||
CC | 13 | 38.2 | 3 | 27.3 | ||
CT | 18 | 52.9 | 7 | 63.6 | 1.7 [0.4 to 7.4] | 0.720 |
TT | 3 | 8.82 | 1 | 9.1 | ||
rs2596622 | n | % | n | % | TT vs. TC plus CC | |
Genotype | ||||||
TT | 15 | 44.1 | 3 | 27.3 | ||
TC | 16 | 47.0 | 8 | 72.7 | 2.1 [0.5 to 9.3] | 0.482 |
CC | 3 | 8.8 | 0 | 0 | ||
rs77624520 | n | % | n | % | ||
Genotype | ||||||
GG | 33 | 97.0 | 11 | 100 | ||
GC | 1 | 3 | 0 | 0 | n.a | n.a |
CC | 0 | 0 | 0 | 0 | ||