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Figure 8 | Journal of Translational Medicine

Figure 8

From: A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response

Figure 8

Comparison of whole blood and PBMC responses in the presence of immunosuppression. The effect of the calcinuerin inhibitor tacrolimus on T cell responses to antigen was assessed in whole blood (left panel) and PBMCs (right panel). Incubation with 20 ng/ml tacrolimus (clear bars) but not PBS (black bars) significantly inhibited antigen-specific T cell responses in whole blood when compared with PBMCs. Mean RQ values and the 95% confidence interval are shown normalized to the ACTs response for PBS-incubated samples.

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