Figure 1
Determination of the immunogenicity of the gastric tumor cell lines mGC8 and 424GC. Mice were vaccinated s.c. with 107 irradiated tumor cells. After 2 weeks, vaccinated and control mice were s.c. injected with 3 × 106 viable tumor cells and tumor growth was monitored. (A) Development of s.c. tumors after vaccination and challenge with mGC8 cells. Representative result of one of three independent experiments is shown. Each line represents a single mouse (n = 5). (B) Tumor-free survival as observed after treatment as described in A; sum of three independent experiments; vaccine group n = 15, control group n = 13. (C) Tumor-free survival following vaccination with mGC8 and challenge with 424GC cells, sum of two independent experiments (n = 10; control group n = 9). (D) Tumor-free survival after vaccination and challenge with 424GC, sum of two independent experiments (n = 10; control group n = 13).