Table 4 Multi-level logistic regression models for virological response in patients with >2 previous failure (n = 533) with GRT+rPRT compared to GRT *
Model | Univariate OR (95% CI) | Multivariate OR (95% CI) | Adjusted p-value |
|---|---|---|---|
Type of resistance test (GRT+rPRT vs. PRT) | 1.45 (1.00 - 2.09) | 1.68 (1.31 - 2.15) | <0.001 |
Age (≥40 vs. <40) | 1.10 (0.74 - 1.64) | 1.22 (0.90 - 1.65) | 0.20 |
Male | 0.77 (0.45 - 1.32) | 0.80 (0.40 - 1.61) | 0.53 |
Current IDU or in drug maintenance programme | 1.27 (0.58 - 2.78) | 1.94 (0.97 - 3.90) | 0.06 |
Baseline HIV RNA (log10 copies/mL) | 0.83 (0.66 - 1.05) | 0.87 (0.64 - 1.18) | 0.37 |
CD4 nadir (square root per 100 cells/μL) | 1.66 (1.18 - 2.32) | 1.67 (1.16 - 2.41) | 0.006 |
Number of previous ART regimens | 0.94 (0.88 - 1.00) | 0.95 (0.90 - 1.00) | 0.07 |
ART regimen after RT test | |||
NNRTI | Reference | Reference | |
PI non-boosted | 0.12 (0.02 - 0.78) | 0.13 (0.03 - 0.64) | 0.01 |
PI boosted | 0.31 (0.16 - 0.59) | 0.43 (0.23 - 0.79) | 0.007 |
Triple nucleoside/Other | 0.08 (0.02 - 0.28) | 0.08 (0.02 - 0.27) | <0.001 |
Missed doses# | |||
0 | Reference | Reference | |
1 | 0.52 (0.27 - 0.98) | 0.42 (0.22 - 0.82) | 0.01 |
2 | 0.41 (0.16 - 1.05) | 0.41 (0.14 - 1.22) | 0.11 |
>2 | 0.41 (0.29 - 0.58) | 0.37 (0.24 - 0.57) | <0.001 |