Skip to main content

Table 4 Uni- and multivariate cox model for overall survival including clinicopathological variables and TLR4 Asp299Gly SNP genotype - hazard ratio point estimates, 95% CIs and p-values (2-sided) from Wald-tests are reported

From: Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas

 

Univariate

cox model

Multivariate

cox model*

 

hazard ratio [95% CI]

P

hazard ratio

[95% CI]

P

TLR4 Asp299Gly genotype

    

   Asp299Asp

1

-

1

-

   Asp299Gly

2.00 [1.02...3.92]

0.04

2.02 [1.01...4.06]

0.05

Age

    

[per 5 years]

1.11 [0.98...1.25]

0.10

  

Sex

    

   female

1

-

1

-

   male

2.55 [1.03...6.36]

0.04

2.91 [1.15...7.32]

0.02

Smoking#

    

   no

1

-

  

   yes

0.91

[0.42...2.00]

0.82

  

AJCC stage

    

   I

1

-

1

-

   II

1.86 [0.70...4.97]

0.21

1.87 [0.70...5.00]

0.21

   III

2.40 [0.89...6.50]

0.08

2.25 [0.83...6.11]

0.11

   IV§

4.08 [1.72...9.66]

1.1 × 10-3

4.66 [1.96...11.09]

5.0 × 10-4

  1. # using 'Mean pack years' instead had no impact on the findings; § which summarizes stages IVA, IVB and IVC
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us