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Table 1 Associations between TLR4 Asp299Gly SNP genotype and clinicopathological variables

From: Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas

 

Total

Asp299Asp

Asp299Gly

P

n (%)

138

125 (90.6)

13 (9.4)

 

   Oro-Hypopharyngeal SCC; n (%)

37

34 (91.9)

3 (8.1)

0.76

   Laryngeal SCC; n (%)

101

90 (89.1)

11 (10.9)

 

Mean age ± SD [years]

61 ± 10

60 ± 10

63 ± 13

0.66

Median follow up [months] (range)#

50 (0-129)

52 (0-129)

42 (8-98)

0.37

Sex (male/female); n

119/19

106/19

13/0

0.21

Smoking; n (%)

124 (89.8)

112 (89.6)

12 (92.3)

1.00

Mean pack years ± SD

45 ± 25

45 ± 24.6

50 ± 29.6

0.62

Primary therapy

   

0.02

   Surgery alone; n (%)

61

57 (45.6)

4 (30.8)

 

   Surgery + RCT§; n (%)

54

51 (40.8)

3 (23.1)

 

   Primary RCT§; n (%)

23

17 (13.6)

6 (46.1)

 

AJCC stage

   

0.53

   I; n (%)

25

22 (17.6)

3 (23.1)

 

   II; n (%)

33

30 (24.0)

3 (23.1)

 

   III; n (%)

25

22 (17.6)

3 (23.1)

 

   IVA; n (%)

50

47 (37.6)

3 (23.1)

 

   IVB; n (%)

3

2 (1.6)

1 (7.6)

 

   IVC; n (%)

2

2 (1.6)

0 (0.0)

 

Grade

   

0.32

   1; n (%)

9

7 (5.6)

2 (15.4)

 

   2; n (%)

96

87 (69.6)

9 (69.2)

 

   3-4; n (%)

25

23 (18.4)

2 (15.4)

 
  1. # as based on the observed data (ignoring censoring); §RCT: radiation + chemotherapy