Table 1 Obesity-related anthropometric measurements and metabolic components in moderately-severely obese females, grouped according to menopausal status
From: Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females
Study group | Pre-menopause | Post-menopause | Normal values/ Range | p values | |
|---|---|---|---|---|---|
Subjects | n.48 | n. 34 | n. 14 | ||
BMI | 35.5 ± 6.2 | 35.4 ± 6.8 | 35.6 ± 4.5 | / | NS |
Waist circumference | 110.8 ± 15.9 | 110.1 ± 16.5 | 112.6 ± 14.6 | < 88 cm | NS |
Fat mass % | 40.1 ± 7.2 | 39.2 ± 8.8 | 42.2 ± 4.7 | 16-30% | NS |
FPG | 92.4 ± 11.5 | 91.1 ± 11.4 | 95.8 ± 11.6 | 60-110 mg/dl | NS |
FPI | 14.4 ± 9.2 | 14.4 ± 9.0 | 14.1 ± 10.2 | 1-20 μU/ml | NS |
HOMA | 3.3 ± 2.2 | 3.3 ± 2.1 | 3.5 ± 2.8 | ≤ 2.5 | NS |
Total cholesterol | 198.1 ± 33.2 | 192.6 ± 30.4 | 211.5 ± 37.3 | ≤ 190 mg/dl | NS |
HDL cholesterol | 52.3 ± 21.3 | 54.4 ± 24.7 | 50.3 ± 7.6 | ≥ 45 mg/dl | NS |
Triglycerides | 124.5.8 ± 72.2 | 121.6.8 ± 62.1 | 142.0 ± 81.9 | ≤ 150 mg/dl | NS |
SBP | 129.4 ± 17.8 | 126.3 ± 14.7 | 136.7 ± 22.4 | ≤ 120 mmHg | NS |
DBP | 84.1 ± 10.8 | 83.4 ± 10.2 | 89.3 ± 11.9 | ≤ 80 mmHg | NS |
AST | 23.6 ± 14 | 18.9 ± 3.8 | 24.3 ± 14.5 | < 35 U/L | NS |
ALT | 32.5 ± 31.3 | 33.8 ± 32.6 | 23.3 ± 6.9 | < 35 U/L | NS |
Uric acid | 4.5 ± 1.2 | 4.4 ± 1.0 | 4.6 ± 09 | 2.4-5.7 mg/dl | NS |
CRP | 2.9 ± 2.7 | 3.2 ± 2.5 | 2.4 ± 2.1 | ≤ 1.6 mg/dl | NS |
SLD | 112.9 ± 12.9 | 112.9 ± 12.9 | 109.5 ± 12.2 | ≤ 110 mm | NS |
IGF-I | 167.8 ± 80.2 | 175.5 ± 91.5 | 148.4 ± 36.5 | 100-494 μg/l | NS |
IGF-I zSDS | -1.9 ± 1.7 | -1.9 ± 2.0 | -2.0 ± 1.0 | / | NS |
IGFBP-1 | 18.8 ± 14.5 | 19.4 ± 15.8 | 17.5 ± 12.6 | / | NS |
IGFBP-3 | 4445.4 ± 1331.1 | 4478.8 ± 1290.5 | 4369.3 ± 1467.2 | 2670-5580 ng/ml | NS |
IGF-I/IGFBP3 | 0.027 ± 0. 01 | 0.027 ± 0. 01 | 0.028 ± 0.01 | / | NS |
AST/platelet index ratio | 0.45 ± 4.7 | 0.44 ± 4.2 | 0.48 ± 5.6 | < 0.76 | NS |
Hepatic steatosis | 41 | 29 | 12 | / | NS |