| |
Her2 (membranous staining)
|
Her3 (membranous staining)
|
Her3 (cytoplasmic staining)
|
|---|
| |
Negative (%)
|
Positive (%)
|
P
|
Negative (%)
|
Positive (%)
|
P
|
Negative (%)
|
Positive (%)
|
P
|
|---|
|
Primary tumors
|
283 (73.1)
|
104 (26.9)
| |
353 (91.2)
|
34 (8.8)
| |
87 (22.5)
|
300 (77.5)
| |
|
Age
| | | | | | | | | |
|
Median
|
61.0
|
61.0
|
0.866
|
60.0
|
63.1
|
0.140
|
61
|
61
|
0.972
|
|
Range
|
23 - 88
|
20 - 95
| |
20 - 95
|
41 - 81
| |
24 - 95
|
20 - 88
| |
|
Gender
| | | | | | | | | |
|
Male
|
217 (74.3)
|
75 (25.7)
|
0.355
|
271 (92.8)
|
21 (7.2)
|
0.052
|
66 (22.3)
|
227 (77.7)
|
0.856
|
|
Female
|
66 (69.5)
|
29 (30.5)
| |
82 (86.3)
|
13 (13.7)
| |
22 (23.2)
|
73 (76.8)
| |
|
Primary tumor sites
| | | | | | | | | |
|
Larynx
|
137 (74.9)
|
46 (25.1)
|
0.557
|
164 (89.6)
|
19 (10.4)
|
0.345
|
39 (21.3)
|
144 (78.7)
|
0.541
|
|
Oral cavity
|
116 (73.9)
|
41 (26.1)
| |
147 (93.6)
|
10 (6.4)
| |
36 (22.9)
|
121 (77.1)
| |
|
Pharynx
|
14 (60.9)
|
9 (39.1)
| |
21 (91.3)
|
2 (8.7)
| |
8 (34.8)
|
15 (65.2)
| |
|
Nasal cavity
|
10 (62.5)
|
6 (37.5)
| |
13 (81.3)
|
3 (18.7)
| |
2 (12.5)
|
14 (87.5)
| |
|
Salivary gland
|
6 (75.0)
|
2 (25.0)
| |
8 (100)
|
0 (0.0)
| |
2 (25.0)
|
6 (75.0)
| |
|
Histological grading1
| | | | | | | | | |
|
Grade 1
|
71 (79.8)
|
18 (20.2)
|
0.021
|
85 (95.5)
|
4 (4.5)
|
0.150
|
24 (27.0)
|
65 (73.0)
|
0.244
|
|
Grade 2
|
157 (68.3)
|
73 (31.7)
| |
208 (90.4)
|
22 (9.6)
| |
54 (23.5)
|
176 (76.5)
| |
|
Grade 3
|
49 (83.1)
|
10 (16.9)
| |
51 (86.4)
|
8 (13.6)
| |
9 (15.3)
|
50 (84.7)
| |
|
Lymph node metastasis2
| | | | | | | | | |
|
No
|
265 (73.0)
|
98 (27.0)
|
0.343
|
331 (91.2)
|
32 (8.8)
|
0.430
|
82 (22.6)
|
281 (77.4)
|
0.295
|
|
Yes
|
13 (81.2)
|
3 (18.8)
| |
14 (87.5)
|
2 (12.5)
| |
5 (31.2)
|
11 (68.8)
| |
- 1Histological grading data were available for 378 cases (97.7%).
- 2Lymph node metastases data were available for 379 cases (97.9%).
