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Table 2 Correlations between Her2/Her3 Expression and Clinicopathological Parameters

From: Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma

  Her2 (membranous staining) Her3 (membranous staining) Her3 (cytoplasmic staining)
  Negative (%) Positive (%) P Negative (%) Positive (%) P Negative (%) Positive (%) P
Primary tumors 283 (73.1) 104 (26.9)   353 (91.2) 34 (8.8)   87 (22.5) 300 (77.5)  
   Age          
Median 61.0 61.0 0.866 60.0 63.1 0.140 61 61 0.972
Range 23 - 88 20 - 95   20 - 95 41 - 81   24 - 95 20 - 88  
   Gender          
Male 217 (74.3) 75 (25.7) 0.355 271 (92.8) 21 (7.2) 0.052 66 (22.3) 227 (77.7) 0.856
Female 66 (69.5) 29 (30.5)   82 (86.3) 13 (13.7)   22 (23.2) 73 (76.8)  
   Primary tumor sites          
Larynx 137 (74.9) 46 (25.1) 0.557 164 (89.6) 19 (10.4) 0.345 39 (21.3) 144 (78.7) 0.541
Oral cavity 116 (73.9) 41 (26.1)   147 (93.6) 10 (6.4)   36 (22.9) 121 (77.1)  
Pharynx 14 (60.9) 9 (39.1)   21 (91.3) 2 (8.7)   8 (34.8) 15 (65.2)  
Nasal cavity 10 (62.5) 6 (37.5)   13 (81.3) 3 (18.7)   2 (12.5) 14 (87.5)  
Salivary gland 6 (75.0) 2 (25.0)   8 (100) 0 (0.0)   2 (25.0) 6 (75.0)  
   Histological grading1          
Grade 1 71 (79.8) 18 (20.2) 0.021 85 (95.5) 4 (4.5) 0.150 24 (27.0) 65 (73.0) 0.244
Grade 2 157 (68.3) 73 (31.7)   208 (90.4) 22 (9.6)   54 (23.5) 176 (76.5)  
Grade 3 49 (83.1) 10 (16.9)   51 (86.4) 8 (13.6)   9 (15.3) 50 (84.7)  
   Lymph node metastasis2          
No 265 (73.0) 98 (27.0) 0.343 331 (91.2) 32 (8.8) 0.430 82 (22.6) 281 (77.4) 0.295
Yes 13 (81.2) 3 (18.8)   14 (87.5) 2 (12.5)   5 (31.2) 11 (68.8)  
  1. 1Histological grading data were available for 378 cases (97.7%).
  2. 2Lymph node metastases data were available for 379 cases (97.9%).