Figure 1
From: Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
Proton leak curves expressed by oxygen consumption (nAgO·mg-1·min-1) and Mitochondrial Membrane Potential (MMP, in arbitrary units) in state 4 (without ADP). Proton leak rates express proton "escape" into mitochondrial matrix contributing to the dissipation of the MMP under pathological conditions. Mitochondria from untreated aging rats needed to consume more oxygen to reach the same value of MMP compared with young controls and old rats treated with IGF-II.