Figure 1
From: Cytotoxic T lymphocyte responses against melanocytes and melanoma
Representative FACS plot showing degranulation in HLA-A*0201-restricted gp100-specific CTL clones. CD107 mobilization quantification in gp100-specific, (A) high RE, and (B) intermediate RE CTL clones upon activation by target melanoma and melanocyte lines. CTL clones demonstrated MHC-restricted, peptide specific response against target cells with RE corresponding to levels as previously described [17]. All melanoma cell lines are HLA-A*0201-positive; melanocyte lines 4C0197 and 3C0661 are A*0201-positive while 3C0659 and 3C074 are A*0201-negative.