Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib

Table 5 Multivariate analysis of variables with significant relationships with clinical outcome in univariate analysis using the Cox proportional hazard model

Variable	n	Hazard ratio (95% CI)	Log-rank P-value
Time to progression	37
ECOG PS (0 vs. 1)		2.692 (0.987-7.34)	0.053
Baseline VEGF-C (ng/mL)^†		0.414 (0.181-0.95)	0.037*
Overall survival	28
Child-Pugh class (A vs. B)		4.053 (1.011-16.25)	0.0480*
ECOG PS (0 vs. 1)		4.875 (1.647-14.43)	0.0042*
sVEGFR-2 ratio to baseline at C1D28^†		0.0257 (0.0001-0.681)	0.0290*

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