Table 3 Median time to progression (TTP) and overall survival (OS) in patients stratified by above/below median baseline, and by above/below median ratio to baseline, soluble protein level.

54.9

21.0

34.0

0.0941

2.15 (0.88, 5.25)

822.2

7.93

34.00

0.0096*

4.12 (1.41, 12.02)

7068

11.71

34.00

0.1641

1.84 (0.78, 4.33)

822.2

18.57

45.00

0.0165*

2.53 (1.19, 5.41)

48,700

57.00

24.64

0.0673

0.50 (0.24, 1.05)

Median ratio to baseline

Median time to event, weeks

Log-rank

P -value

Hazard ratio

(95% CI)

Patients with

≤ median ratio to baseline ^†

Patients with

> median ratio to baseline ^†

2.2269

34.0

11.7

0.0225*

0.30 (0.11, 0.84)

0.9153

42.9

32.4

0.1341

0.44 (0.15, 1.29)

2.0923

42.9

21.0

0.0034*

0.15 (0.04, 0.53)

0.6596

32.43

11.71

0.0347*

0.29 (0.09, 0.92)

0.6385

48.43

34.07

0.0192*

0.16 (0.04, 0.74)

0.2195

16.14

46.29

0.0028*

5.54 (1.80, 17.02)

0.8221

34.14

16.14

0.0476*

0.33 (0.11, 0.99)

0.4067

22.00

42.86

0.1182

2.35 (0.80, 6.84)

2.2269

69.00

18.79

0.0142*

0.36 (0.16, 0.82)

0.9153

57.00

22.21

0.0862

0.45 (0.18, 1.12)

0.7388

45.00

21.21

0.0291*

0.37 (0.15, 0.90)

0.6596

57.00

18.57

0.0452*

0.38 (0.15, 0.98)

0.4558

20.50

71.21

0.0041*

3.96 (1.55, 10.12)

0.8221

45.00

27.50

0.1356

0.55 (0.25, 1.21)

0.4067

40.79

73.43

0.0218*

0.37 (1.21, 11.48)