Figure 3

Mutational profile of samples. Tissue samples are displayed across the top and annotations relevant to them are in columns below. Red boxes denote DNA amplification and concordant mRNA overexpression, orange boxes denote RNA overexpression with no evidence of DNA amplification, red dots denote DNA loss. Blue boxes denote somatic nonsynonymous mutation validated by Sanger sequencing and purple boxes denote nonsynonymous somatic mutations, observed in the Illumina data with no attempt to confirm by Sanger sequencing. Amino changes are noted in the boxes and changes leading to loss or gain of a stop codon are in red text.