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Table 2 Serum levels of cytokines, chemokines, and growth factors according to age.

From: Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays

Cytokines

(pg/ml)

Group 1

(Age < 45)

Group 2

(Age ≥ 65)

P-valuea

G-CSF

14.7 ± 13.2b (0.03-75.8)

9.9 ± 8.8 (0.03-35.2)

0.009

GM-CSF

40.9 ± 108.6 (0.5-728.1)

20.3 ± 60.40 (0.50-415.1)

0.021

MCP 1

213.5 ± 100.7 (27.9-667.8)

168.0 ± 73.0 (39.34-355.9)

0.027

sCD40L

2205.8 ± 4699.2 (268.6-27703.8)

20370.6 ± 71662.0 (115.8-380396.7)

0.016

TGF-α

3.2 ± 4.0 (0.93-26.8)

4.9 ± 4.8 (0.86-20.8)

0.026

EGF

31.3 ± 35.9 (3.2-210.5)

61.0 ± 65.1 (3.20-251.6)

0.073

FGF-2

18.9 ± 11.3 (6.7-65.6)

20.1 ± 13.9 (3.20-72.83)

0.863

Flt-3L

10.2 ± 10.1 (0.84-59.3)

13.2 ± 15.9 (0.03-78.42)

0.759

IFN-α2

21.3 ± 22.6 (2.42-102.2)

33.3 ± 70.2 (2.42-449.2)

0.822

IFN-γ

13.1 ± 22.7 (0.14-126.8)

10.3 ± 18.4 (1.09-117.7)

0.948

IL-10

1.32 ± 3.06 (0.01-19.8)

1.58 ± 6.17 (0.01-41.7)

0.325

IL-15

3.04 ± 2.17 (1.25-13.1)

3.49 ± 4.31 (1.32-28.9)

0.668

IL-17

6.53 ± 7.42 (1.58-37.8)

12.2 ± 37.9 (1.43-275.1)

0.640

IL-1β

2.04 ± 4.93 (0.17-24.)

2.52 ± 7.41 (0.17-39.0)

0.645

IL-2

5.13 ± 2.31 (2.88-18.3)

5.58 ± 4.17 (3.06-32.1)

0.601

IL-6

2.91 ± 6.45 (0.16-37.7)

2.57 ± 5.22 (0.16-31.5)

0.750

IL-8

23.9 ± 29.7 (4.2-132.6)

27.6 ± 43.9 (4.76-217.0)

0.995

IP-10

462.2 ± 364.7 (145.3-2152.2)

451.3 ± 256.4 (149.8-1394.8)

0.673

MIP-1β

40.5 ± 38.8 (3.2-227.2)

40.4 ± 33.6 (3.20-231.1)

0.633

PDGF-AA

1528.3 ± 878.8 (140.6-3290.2)

1615.3 ± 1125.0 (55.3-3421.7)

0.485

TNF-α

3.21 ± 4.04 (0.93-26.8)

4.94 ± 4.79 (0.86-20.8)

0.916

VEGF

114.9 ± 147.1 (13.1-864.1)

100.5 ± 75.4 (6.9-329.3)

0.853

  1. aDifferences with P < 0.05 are considered significant.
  2. bAverage concentrations ± standard deviation in pg/mL.