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Table 1 Clinical information of AMD patients

From: Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

PT number

Race, Age, Gender

Type of Disease

CFH rs1061170

C2/CFB

Rs933739

C3

Rs2230199

Ocular therapy+

Co-Morbidities*

Medications++

1

W, 94, F

Wet OU

TC

GG

CC

anti-VEGF, PDT

19

H

2

W, 80, F

Wet OU

TT

GG

CC

anti-VEGF, PDT

8

W, L, X

3

W, 97, F

Wet OU

TC

GG

CC

anti-VEGF, Isteroids

none

W

4

W, 92, F

Wet OU

TC

GG

CC

anti-VEGF

14, 16, 21

Z, G, O, BB

5

W, 91, M

Wet OU

TC

GG

CC

anti-VEGF

2, 7, 18, 14

W, H, T, G, D, C, B

6

W, 91, M

Wet OU

TC

GG

CG

anti-VEGF

10, 11, 14, 15

G, C, H, B, E

7

W, 83, F

Wet OU

CC

GG

CG

anti-VEGF, PDT

8, 14, 16

W, Z, G

8

W, 79, F

Wet OD, Dry OS

CC

GG

CG

anti-VEGF, Laser Rx

14, 15, 21

W, C, G, M, BB

9

W, 74, M

Wet OU

CC

GG

GG

anti-VEGF, Laser Rx

7, 11, 14, 15

W, BB, E, Y, D, H, L, C, S

10

W, 77, M

Wet OD, Dry OS

TC

GG

CG

anti-VEGF, Isteroids

14, 15

W, L, C, H, R

11

W, 74, M

Dry OD, Wet OS

TT

GG

CC

anti-VEGF

3, 15, 16

W, Z, A

12

W, 82, F

Wet OU

TT

GG

GG

anti-VEGF, PDT

10, 11

W, E, BB, L, F

13

W, 81, F

Wet OU

CC

GG

CG

anti-VEGF, laser Rx

7, 14, 15

C, G, V

14

W, 75, M

Wet OD, Dry OS

TC

GG

CC

None

14, 15, 23

C, G, H

15

W, 67, M

Wet OD, Dry OS

TC

GG

CC

anti-VEGF, PDT

8, 15, 20

W, L, X, C, H, F

16

W, 72, F

Wet OU

TC

GG

CC

anti-VEGF, Isteroids

12, 16

Z, I, G, W

17

W, 74, M

Wet OU

CC

CG

GG

anti-VEGF, laser Rx, PDT

20

F, V

18

W, 77, F

Wet OU

CC

-

CC

anti-VEGF, PDT, Isteroid

8

X

19

W, 75, M

Dry OD, Wet OS

CC

GG

CC

anti-VEGF

11, 15

W, E, C, L

20

W, 82, M

Wet OU

-

-

-

none

3, 5, 6, 7, 11, 19,

P, B, G, A, E, D

21

W, 72, M

Wet OU

CC

GG

CG

anti-VEGF, Isteroid

7, 14

H, G, D

22

W, 83, M

Wet OD, Dry OS

TC

GG

CC

anti-VEGF, Isteroid

14, 15

W, L, H, G, C

23

W, 83, M

Wet OD, Dry OS

TT

GG

GG

anti-VEGF, PDT

14, 15, 22

B, W, G, C,

24

W, 88, F

Dry OD, Wet OS

TC

GG

CC

anti-VEGF

19

W, H,

25

W, 70, M

Wet OD, Dry OS

TC

GG

CC

anti-VEGF

10

W

26

W, 83, F

Wet OD, Dry OS

TT

GG

CC

anti-VEGF, Isteroids

8, 13, 14, 17,

Q, G, Z, W

27

W, 80, M

Dry OD, Wet OS

CC

GG

CG

anti-VEGF

7, 8, 14, 15, 21, 25

W, L, BB, Q, G, C, M, AA, D, BB

28

W, 95, M

Dry OD, Wet OS

TT

CG

CC

anti-VEGF

1, 14, 15, 22

W, E, B, K, BB, C, G, T,

29

W, 79, F

Wet OU

CC

GG

CG

anti-VEGF, PDT

7, 21, 24

W, L, D, V, CC, N

30

W, 84, M

Wet OU

TC

GG

CC

PDT, Laser Rx

5, 8

G, H, C, X, A,

31

W, 80, M

Wet OD, Dry OS

CC

CG

CG

anti-VEGF

4, 8, 15

W, BB, L, B, E, N, D, X

32

W, 97, F

Wet OU

-

-

-

None

2

J, B

33

W, 77, M

Wet OU

TC

GG

CC

anti-VEGF, Laser Rx

11

W, L, E

34

W, 57, M

Wet OU, Wet OS

TT

GG

CG

anti-VEGF

3, 7, 14, 15, 26

A, C, D, G, BB, DD

35

W, 67, F

Wet OU

CT

GG

CG

anti-VEGF

14, 15, 16, 21

G, M, Z, BB, EE

36

W, 82, F

Wet OU

CT

CG

CG

anti-VEGF

7, 8, 14, 15, 16

C, G, K, Q, Z, BB

37

W, 84, F

Wet OS

CC

GG

CC

anti-VEGF

15, 16

CC, L, G, Z,

38

W, 83, F

Wet OU

CT

GG

CG

anti-VEGF

9, 14, 15, 28

B, C, BB

39

W, 84, F

Wet OS

TT

GG

CC

anti-VEGF

16, 27

Z, CC

40

W, 90, F

Wet OU

CC

GG

CC

anti-VEGF

27

B, G, H, O, BB, CC

  1. Ocular therapy+
  2. anti-VEGF- either Lucentis or Avastin intravitreal injections; Isteroids-Intravitreal steroid injections; PDT- Photodynamic
  3. therapy; Laser Rx- focal laser ablation of choroidal neovascularization
  4. Co-morbidities*
  5. 1. anemia; 2. atrial fibrillation; 3. benign prostatic hypertrophy; 4. cerebrovascular accident; 5. COPD; 6. coronary artery disease; 7. depression; 8. diabetes; 9. Colon Cancer; 10. Glaucoma; 11. GERD; 12. gout; 13. Hashimoto's thyroiditis; 14. hypertension; 15. hypercholesterolemia; 16. hypothyroid; 17. h/o low grade vitritis; 18. Lyme Disease; 19. myocardial infarction; 20. Ocular Hypertension; 21. osteoporosis; 22. pacemaker; 23. prostate cancer; 24. seasonal allergies 25. testicular failure; 26. Asthma; 27. Uterine cancer post hysterectomy and radiation 28: Breast cancer.
  6. Medications++
  7. A. Anti-Benign Prostatic Hypertrophy; B. Anti-Coagulants; C. Anti-Cholesterol; D. Anti-Depressants; E. Anti-GERD; F. Anti-Glaucoma drops; G. Anti-Hypertensive medication; H. Aspirin; I. Colchicine; J. Digoxin; K. Ferrous Fumarate; L. Fish Oil; M. Fosamax; N. Gapapentin; O. Glucosamine; P. Inhalers; Q. Insulin; R. Loratadine; S. Magnesium Citrate; T. Meclizine; U. Megestrol acetate; V. NSAIDs; W. Ocuvites; X. Oral Hypoglycemic agents; Y. Scopolamine; Z. Synthroid; AA. Testosterone injections; BB. Vitamins; CC. Premarin; DD. Singulair; EE. Calcitonin.