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Table 2 Tumor expression of FGF2, FGFR-1 and the co-expressions of FGF2 & PDGF-B and FGF2 & VEGFR-3 and their prediction for disease-specific survival in patients with completely resected non-gastrointestinal stromal tumor soft-tissue sarcomas (univariate analyses, log rank test; multivariate analysis, Cox regression analysis)

From: Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

 

Univariate analyses

Multivariate analysis

Marker expression

Patients

(n)

Patients

(%)

Median

survival

(months)

5-Year

survival

(%)

P

HR

95% CI

P

FGF2

        

Low

75

69

NR

68

0.048

1.000

  

High

30

28

54

50

 

2.203

1.108-4.379

0.024

Missing

3

3

      

FGFR-1

        

Low

78

72

NR

61

0.830

   

High

28

26

NR

62

    

Missing

2

2

      

FGF2 & PDGF-B

       

0.007*

Low

27

25

NR

81

0.011

1.000

  

Intermediate

52

48

NR

59

 

3.569

1.311-9.715

0.013

High

25

23

45

48

 

5.971

1.966-18.132

0.002

Missing

4

4

      

FGF2 & VEGFR-3

       

0.050*

Low

51

47

NR

70

0.042

1.000

  

Intermediate

35

32

120

56

 

1.999

0.978-4.087

0.058

High

16

15

45

46

 

2.584

1.106-6.038

0.028

Missing

6

6

      

FGFR-1 & PDGF-B

        

Low

26

24

NR

75

0.061

   

Intermediate

56

52

120

55

    

High

23

21

NR

58

    

Missing

3

3

      

FGFR-1 & VEGFR-3

        

Low

57

53

NR

66

0.344

   

Intermediate

29

27

120

59

    

High

18

17

63

52

    

Missing

4

4

      
  1. Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; NR, not reached; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; *overall significance as prognostic factor.
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Journal of Translational Medicine

ISSN: 1479-5876

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