Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFβ1-signaling and increased Galectin-3 expression: A histological study on biopsies

Table 1 Quantitative anlysis of immunohistochemistry results.

Protein	TGFβ1			Smad-2/3			Smad-7			Galectin-3
Tissue source	Median IQR	SD	R	Median IQR	SD	R	Median IQR	SD	R	Median IQR	SD	R
Normal	38.03 11	7.92	33	35.95 8	5.73	28	40.93 14	8.93	44	15.15 7	4.8	23
BRONJ-related	20.68 8	5.24	26	17.16 8	5.22	20	62.83 15	11.3	45	44.44 20	12	45
Osteoradionecrosis-related	61.01 23	12.2	38	52 14	6.75	19	18.01 10	7.98	25	29.02 8	5.8	19

Relative labeling indices for targeted proteins among normal, BRONJ-related, and osteoradionecrosis-related mucoperiosteal tissues. Values represent the median, interquartile range (IQR), standard deviation (SD), and range (R).
BRONJ: bisphosphonate-associated osteonecrosis of the jaw

ISSN: 1479-5876