Figure 2
AURKA expression patterns in NSCLC correlate with tumor subtype and tumor differentiation grade. Box plot diagrams showing the modulations of AURKA mRNA in 83 NSCLC subtypes specimens. A) AURKA was significantly up-modulated in: squamous, adeno and large cells carcinomas (p = 0.029). B) AURKA was significantly up-modulated in moderately and poorly differentiated lung cancers (p < 0.01). Dotted lines correspond to a cut-off of ± 2 fold changes (log2(FC) ± 1). ADC = Adenocarcinoma, SQC = Squamous cell carcinoma, BAC = Bronchiolo-alveolar carcinoma and LCC = Large cell carcinoma. Values in parentheses indicate the patients' number in each subgroups.