MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status

Table 2 MMP-1 expression of the study population in different tissues

Tissue	n	Median expression (%)	IQR (%)	95% CI	p-value
BE without intraepithelial neoplasia or carcinoma (GERD)	18	4	0-11	0-10.603
BE adjacent EAC	41	35	23.0-41.5	31.284-39.0	<0.05^†
Adjacent EAC to BE	41	48	39.0-56.5	43.0-54.239	<0.05^††
EAC without BE	19	44	39.0-55.8	39.0-55.218	<0.05^††
ESCC	10	27	0-50.2	0-29.2	<0.05^†††

BE, Barrett metaplasia; GERD, Gastro-Esophageal Reflux Disease; EAC, esophageal adenocarcinomas; ESCC, esophageal squamous-cell carcinomas; ^†significance is related to GERD; ^††significance is related to BE with adjacent EAC; ^†††significance is related to EACs

ISSN: 1479-5876