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Figure 3 | Journal of Translational Medicine

Figure 3

From: MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status

Figure 3

Correlation and co-expression of Ki-67 with MMP-1. Correlation from quantified immunohistochemical staining results of MMP-1+ in BE (n = 41) and EAC (n = 60) with proliferating cells (Ki-67+) showed that Ki-67+ expression in BE (a) and EACs (b) had a strong direct correlation with the expression of MMP-1+ (r = 0.943 for BE and r = 0.811 for EAC). (c) Images demonstrate a representative example of Ki-67 co-expression with MMP-1+ by an immunofluorescent double staining in early BE showing the majority of proliferating (Ki-67+) cells with MMP-1+ (big arrows). Small arrows indicate goblet cells. FITC green Fluoresceinisothiocyanat, Cy3 red, and DAPI 4',6-Diamidino-2-phenylindoldihydrochlorid blue. Top, Calibration bar represents 50 ÎĽm. Bottom, calibration bar represents 25 ÎĽm. The square box at the bottom demonstrates the area which is also shown in larger magnification.

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